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Type: Journal article
Title: Chemokine/Chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7
Author: Faaij, C.
Willemze, A.
Revesz, T.
Balzarolo, M.
Tensen, C.
Hoogeboom, M.
Vermeer, M.
van Wering, E.
Zwaan, C.
Kaspers, G.
Story, C.
van Halteren, A.
Vossen, J.
Egeler, R.
van Tol, M.
Annels, N.
Citation: Pediatric Blood and Cancer, 2010; 55(2):344-348
Publisher: Wiley-Liss
Issue Date: 2010
ISSN: 1545-5009
Statement of
Claudia M.J.M. Faaij, Annemieke J. Willemze, Tom Révész, Melania Balzarolo, Cornelis P. Tensen, Manja Hoogeboom, Maarten H. Vermeer, Elisabeth van Wering, Christian M. Zwaan, Gertjan J.L. Kaspers, Colin Story, Astrid G.S. van Halteren, Jaak M. Vossen, R. Maarten Egeler, Maarten J.D. van Tol and Nicola E. Annels
Abstract: Chemokine receptor/ligand interactions orchestrate the migration of cells to peripheral tissues such as the skin. We analysed chemokine receptor expression by acute myeloid leukaemic (AML) cells present in peripheral blood (n = 7), bone marrow (n = 6), or skin (n = 11) obtained from 15 paediatric AML patients with skin involvement and in 10 AML patients without skin involvement. High percentages of circulating CCR2(pos) AML cells were only detected in patients with extramedullary disease. Skin-residing AML cells displayed a different set of receptors in situ, namely: CCR5, CXCR4, CXCR7 and CX3CR1. These results suggest the involvement of different chemokine/chemokine receptor interactions in homing and retention of AML blasts in the skin.
Keywords: Skin
Skin Neoplasms
Leukemic Infiltration
Receptors, Chemokine
Receptors, CCR5
Receptors, CXCR4
Case-Control Studies
Child, Preschool
Infant, Newborn
Leukemia, Myeloid, Acute
Receptors, CXCR
Receptors, CCR2
CX3C Chemokine Receptor 1
Rights: Copyright © 2010 Wiley-Liss, Inc.
DOI: 10.1002/pbc.22500
Appears in Collections:Aurora harvest 5
Paediatrics publications

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