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|Title:||Experimental colonization of the canine urinary tract with the asymptomatic bacteriuria Escherichia coli strain 83972|
|Citation:||Veterinary Microbiology, 2011; 147(1-2):205-208|
|Publisher:||Elsevier Science BV|
|Mary F. Thompson, Makrina Totsika, Mark A. Schembri, Paul C. Mills, Erica J. Seton, Darren J. Trott|
|Abstract:||Establishment of asymptomatic bacteriuria (ABU) with Escherichia coli 83972 is a viable prophylactic alternative to antibiotic therapy for the prevention of recurrent bacterial urinary tract infection in humans. Approximately 2 × 10(8) viable E. coli 83972 cells were introduced into the bladder of six healthy female dogs via a sterile urinary catheter. The presence of pyuria, depression, stranguria, pollakiuria and haematuria was documented for 6 weeks and urinalysis and aerobic bacterial cultures were performed every 24-72 h. Pyuria was present in all dogs on day 1 post-inoculation and 4/6 dogs (67%) had a positive urine culture on this day. Duration of colonization ranged from 0 to 10 days (median 4 days). Four dogs were re-inoculated on day 20. Duration of colonization following the second inoculation ranged from 1 to 3 days. No dog suffered pyrexia or appeared systemically unwell but all dogs initially exhibited mild pollakiuria and a small number displayed gross haematuria and/or stranguria. By day 3 of each trial all clinical signs had resolved. Persistent bacteriuria was not achieved in any dog but two dogs were colonized for 10 days following a single inoculation. Further research is required to determine whether establishment of ABU in dogs with recurrent urinary tract infection is a viable alternative to repeated doses of antimicrobial agents.|
|Keywords:||Urinary tract infection; Bacteriuria; Canine; Bacterial interference; Colonization|
|Rights:||Crown copyright © 2010 Published by Elsevier B.V.|
|Appears in Collections:||Animal and Veterinary Sciences publications|
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