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Type: Journal article
Title: Kinin receptor antagonists as potential neuroprotective agents in central nervous system injury
Author: Thornton, E.
Ziebell, J.
Leonard, A.
Vink, R.
Citation: Molecules, 2010; 15(9):6598-6618
Publisher: Molecular Diversity Preservation International
Issue Date: 2010
ISSN: 1420-3049
Statement of
Emma Thornton, Jenna M Ziebell, Anna V Leonard and Robert Vink
Abstract: Injury to the central nervous system initiates complex physiological, cellular and molecular processes that can result in neuronal cell death. Of interest to this review is the activation of the kinin family of neuropeptides, in particular bradykinin and substance P. These neuropeptides are known to have a potent pro-inflammatory role and can initiate neurogenic inflammation resulting in vasodilation, plasma extravasation and the subsequent development of edema. As inflammation and edema play an integral role in the progressive secondary injury that causes neurological deficits, this review critically examines kinin receptor antagonists as a potential neuroprotective intervention for acute brain injury, and more specifically, traumatic brain and spinal cord injury and stroke.
Keywords: brain injury; neurotrauma; stroke; neuropeptides; kinins
Rights: © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (
RMID: 0020100973
DOI: 10.3390/molecules15096598
Appears in Collections:Pathology publications

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