Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/61993
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Type: Journal article
Title: The response to repetitive stimulation of human motor cortex is influenced by the history of synaptic activity
Author: Todd, G.
Ridding, M.
Citation: Restorative Neurology and Neuroscience, 2010; 28(4):459-467
Publisher: IOS Press
Issue Date: 2010
ISSN: 0922-6028
1878-3627
Statement of
Responsibility: 
G. Todd and M.C. Ridding
Abstract: Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), can modify cortical excitability in a lasting fashion. The modification can be bi-directional in nature and holds considerable therapeutic promise for a number of neurological conditions. However, the effectiveness of these techniques is currently limited by large intra- and inter-subject variability in the response. A number of factors that contribute to response variability have now been identified, with one of the most important being the history of synaptic activity within the cortical region being targeted by stimulation. In this review we discuss what is currently known about the influence of behaviourally, or experimentally, induced changes in synaptic activity in the cortical (or interconnected) region being targeted by stimulation on the response to rTMS techniques. Understanding such influences is a critical step in the development of effective therapeutic paradigms employing such techniques.
Keywords: Motor Cortex
Synapses
Animals
Humans
Behavior
Individuality
Transcranial Magnetic Stimulation
Rights: © 2010 – IOS Press and the authors. All rights reserved.
DOI: 10.3233/RNN-2010-0565
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