Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLau, D.-
dc.contributor.authorMackenzie, L.-
dc.contributor.authorKelly, D.-
dc.contributor.authorPsaltis, P.-
dc.contributor.authorBrooks, A.-
dc.contributor.authorWorthington, M.-
dc.contributor.authorRajendram, A.-
dc.contributor.authorKelly, D.-
dc.contributor.authorZhang, Y.-
dc.contributor.authorKuklik, P.-
dc.contributor.authorNelson, A.-
dc.contributor.authorWong, C.-
dc.contributor.authorWorthley, S.-
dc.contributor.authorRao, M.-
dc.contributor.authorFaull, R.-
dc.contributor.authorEdwards, J.-
dc.contributor.authorSaint, D.-
dc.contributor.authorSanders, P.-
dc.identifier.citationHeart Rhythm, 2010; 7(9):1282-1290-
dc.description.abstract<h4>Background</h4>Hypertension accounts for more atrial fibrillation (AF) than any other predisposing factor.<h4>Objective</h4>The purpose of this study was to characterize the time course, extent, and electrostructural correlation of atrial remodeling in chronic hypertension.<h4>Methods</h4>Thirty-two sheep were studied: 21 with induced "one-kidney, one-clip" hypertension and 11 controls. Sequential closed-chest electrophysiologic studies were performed in 12 conscious animals (6 hypertensive, 6 controls) to evaluate progressive remodeling over 15 weeks. Additional atrial structural/functional analyses were performed in 5 controls and at 5, 10, and 15 weeks of hypertension (five per time point) via histology/cardiac magnetic resonance imaging to correlate with open-chest electrophysiologic parameters.<h4>Results</h4>The hypertensive group developed a progressive increase in mean arterial pressure (P <.001). Mean effective refractory periods were uniformly higher at all time points (P <.001). Progressive biatrial hypertrophy (P = .003), left atrial dysfunction (P <.05) and greater AF inducibility were seen early with increased inflammation from 5 weeks of hypertension. In contrast, significant conduction slowing (P <.001) with increased heterogeneity (P <.001) along with increased interstitial fibrosis resulted in longer and more fractionated AF episodes only from 10 weeks of hypertension. Significant electrostructural correlation was seen in conduction abnormalities and AF inducibility with both atrial inflammation and fibrosis.<h4>Conclusion</h4>Hypertension is associated with early and progressive changes in atrial remodeling. Atrial remodeling occurs at different time domains in chronic hypertension with significant electrostructural correlation of the remodeling cascade. Early institution of antihypertensive treatment may prevent formation of substrate capable of maintaining AF.-
dc.description.statementofresponsibilityDennis H. Lau, Lorraine Mackenzie, Darren J. Kelly, Peter J. Psaltis, Anthony G. Brooks, Michael Worthington, Arumuga Rajendram, Douglas R. Kelly, Yuan Zhang, Pawel Kuklik, Adam J. Nelson, Christopher X. Wong, Stephen G. Worthley, Mohan Rao, Randall J. Faull, James Edwards, David A. Saint, Prashanthan Sanders-
dc.publisherElsevier Inc.-
dc.rights© 2010 Heart Rhythm Society. All rights reserved.-
dc.subjectAtrial fibrillation-
dc.titleHypertension and atrial fibrillation: Evidence of progressive atrial remodeling with electrostructural correlate in a conscious chronically instrumented ovine model-
dc.typeJournal article-
dc.identifier.orcidLau, D. [0000-0001-7753-1318]-
dc.identifier.orcidPsaltis, P. [0000-0003-0222-5468]-
dc.identifier.orcidKuklik, P. [0000-0001-8440-654X]-
dc.identifier.orcidNelson, A. [0000-0003-0990-2548]-
dc.identifier.orcidWong, C. [0000-0002-1913-6675]-
dc.identifier.orcidSanders, P. [0000-0003-3803-8429]-
Appears in Collections:Aurora harvest
Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.