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Type: Journal article
Title: Clonal group distribution of fluoroquinolone-resistant Escherichia coli among humans and companion animals in Australia
Author: Platell, J.
Cobbold, R.
Johnson, J.
Trott, D.
Citation: Journal of Antimicrobial Chemotherapy, 2010; 65(9):1936-1938
Publisher: Oxford Univ Press
Issue Date: 2010
ISSN: 0305-7453
Statement of
Joanne L. Platell, Rowland N. Cobbold, James R. Johnson and Darren J. Trott
Abstract: Objectives: To determine the phylogenetic group distribution and prevalence of three major globally disseminated clonal groups [clonal group A (CGA) and O15:K52:H1, associated with phylogenetic group D, and sequence type ST131, associated with phylogenetic group B2] among fluoroquinolone-resistant extra-intestinal Escherichia coli isolates from humans and companion animals in Australia. Methods: Clinical extra-intestinal fluoroquinolone-resistant E. coli isolates were obtained from humans (n = 582) and companion animals (n  = 125), on Australia's east coast (October 2007–October 2009). Isolates were tested for susceptibility to seven antimicrobial agents, and for phylogenetic group, O type and clonal-group-specific single nucleotide polymorphisms by PCR. Results: The fluoroquinolone-resistant isolates were typically resistant to multiple agents (median of four). Analysis revealed that clonal group ST131 accounted for a large subset of the human isolates (202/585, 35%), but for a much smaller proportion of the companion animal isolates (9/125, 7.2%; P ≤ 0.001). In contrast, CGA and O15:K52:H1 were uncommon among both human (7.2%) and companion animal (0.8%) isolates. Conclusions: In Australia, a large proportion (42%) of recent fluoroquinolone-resistant extra-intestinal E. coli isolates from humans are represented by three major globally disseminated clonal groups, predominantly ST131, which by contrast is comparatively rare among fluoroquinolone-resistant E. coli from companion animals. In conjunction with Australia's ban on fluoroquinolone use in livestock, these results argue against a major domestic food animal or companion animal source for fluoroquinolone-resistant extra-intestinal E. coli among humans in Australia. However, both humans and companion animals are involved in the intercontinental emergence and dissemination of ST131.
Keywords: ST131; clonal group A; O15:K52:H1; multidrug resistance
Rights: © The Author 2010. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
RMID: 0020100668
DOI: 10.1093/jac/dkq236
Appears in Collections:Agriculture, Food and Wine publications

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