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Type: Journal article
Title: 1,2,3-Triazolyl amino acids as AMPA receptor ligands
Author: Stanley, N.
Pedersen, D.
Nielsen, B.
Kvist, T.
Mathiesen, J.
Brauner-Osborne, H.
Taylor, D.
Abell, A.
Citation: Bioorganic and Medicinal Chemistry Letters, 2010; 20(24):7512-7515
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2010
ISSN: 0960-894X
Statement of
N. J. Stanley, D. Sejer Pedersen, B. Nielsen, T. Kvist, J. M. Mathiesen, H. Bräuner-Osborne, D. K. Taylor and A. D. Abell
Abstract: The central nervous system glutamate receptors are an important target for drug discovery. Herein we report initial investigations into the synthesis and glutamate receptor activity of 1,2,3-triazolyl amino acids. Two compounds were found to be selective AMPA receptor ligands, which warrant further investigation.
Keywords: Synthesis
Glutamate receptor
Rights: Copyright 2010 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.bmcl.2010.09.139
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