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Type: Journal article
Title: Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain
Author: Xu, H.
Stamova, B.
Jickling, G.
Tian, Y.
Zhan, X.
Ander, B.
Liu, D.
Turner, R.
Rosand, J.
Goldstein, L.
Furie, K.
Verro, P.
Johnston, S.
Sharp, F.
DeCarli, C.
Citation: Stroke, 2010; 2010(12):1-6
Publisher: Lippincott Williams & Wilkins
Issue Date: 2010
ISSN: 0039-2499
Statement of
Huichun Xu, Boryana Stamova, Glen Jickling, Yingfang Tian, Xinhua Zhan, Bradley P. Ander, Dazhi Liu, Renee Turner, Jonathan Rosand, Larry B. Goldstein, Karen L. Furie, Piero Verro, S. Claiborne Johnston, Frank R. Sharp, and Charles S. DeCarli
Abstract: Background and Purpose—White matter hyperintensities (WMH) are areas of high signal detected by T2 and fluid-attenuated inversion recovery sequences on brain MRI. Although associated with aging, cerebrovascular risk factors, and cognitive impairment, the pathogenesis of WMH remains unclear. Thus, RNA expression was assessed in the blood of individuals with and without extensive WMH to search for evidence of oxidative stress, inflammation, and other abnormalities described in WMH lesions in brain. Methods—Subjects included 20 with extensive WMH (WMH_), 45% of whom had Alzheimer disease, and 18 with minimal WMH (WMH_), 44% of whom had Alzheimer disease. All subjects were clinically evaluated and underwent quantitative MRI. Total RNA from whole blood was processed on human whole genome Affymetrix HU133 Plus 2.0 microarrays. RNA expression was analyzed using an analysis of covariance. Results— Two hundred forty-one genes were differentially regulated at _1.2-fold difference (P_0.005) in subjects with WMH_ as compared to WMH_, regardless of cognitive status and 50 genes were differentially regulated with _1.5-fold difference (P_0.005). Cluster and principal components analyses showed that the expression profiles for these genes distinguished WMH_ from WMH_ subjects. Function analyses suggested that WMH-specific genes were associated with oxidative stress, inflammation, detoxification, and hormone signaling, and included genes associated with oligodendrocyte proliferation, axon repair, long-term potentiation, and neurotransmission. Conclusions—The unique RNA expression profile in blood associated with WMH is consistent with roles of systemic oxidative stress and inflammation, as well as other potential processes in the pathogenesis or consequences of WMH.
Keywords: Alzheimer disease
gene expression profiling
oxidative stress
white matter
Rights: Copyright: © 2010 American Heart Association, Inc.
DOI: 10.1161/STROKEAHA.110.591875
Appears in Collections:Aurora harvest 5
Pathology publications

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