Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSmith, L.-
dc.contributor.authorSchirer, J.-
dc.contributor.authorFazzalari, N.-
dc.identifier.citationJournal of Biomechanics, 2010; 43(16):3144-3149-
dc.description.abstractIn trabecular bone, each remodeling event results in the resorption and/or formation of discrete structural units called 'packets'. These remodeling packets represent a fundamental level of bone's structural hierarchy at which to investigate composition and mechanical behaviors. The objective of this study was to apply the complementary techniques of quantitative backscattered electron microscopy (qBSEM) and nanoindentation to investigate inter-relationships between packet mineralization, elastic modulus, contact hardness and plastic deformation resistance. Indentation arrays were performed across nine trabecular spicules from 3 human donors; these spicules were then imaged using qBSEM, and discretized into their composite remodeling packets (127 in total). Packets were classified spatially as peripheral or central, and mean contact hardness, plastic deformation resistance, elastic modulus and calcium content calculated for each. Inter-relationships between measured parameters were analysed using linear regression analyses, and dependence on location assessed using Student's t-tests. Significant positive correlations were found between all mechanical parameters and calcium content. Elastic modulus and contact hardness were significantly correlated, however elastic modulus and plastic deformation resistance were not. Calcium content, contact hardness and elastic modulus were all significantly higher for central packets than for peripheral, confirming that packet mineral content contributes to micromechanical heterogeneity within individual trabecular spicules. Plastic deformation resistance, however, showed no such regional dependence, indicating that the plastic deformation properties in particular, are determined not only by mineral content, but also by the organic matrix and interactions between these two components.-
dc.description.statementofresponsibilityLachlan J. Smith, Jeffrey P.Schirer and Nicola L. Fazzalari-
dc.publisherElsevier Sci Ltd-
dc.rightsCopyright 2010 Elsevier Ltd. All rights reserved.-
dc.subjectMicroscopy, Electron-
dc.subjectLinear Models-
dc.subjectBone Remodeling-
dc.subjectBone Density-
dc.subjectStress, Mechanical-
dc.subjectScattering, Radiation-
dc.subjectModels, Biological-
dc.subjectMiddle Aged-
dc.subjectElastic Modulus-
dc.subjectBiomechanical Phenomena-
dc.subjectIn Vitro Techniques-
dc.titleThe role of mineral content in determining the micromechanical properties of discrete trabecular bone remodeling packets-
dc.typeJournal article-
Appears in Collections:Aurora harvest
Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.