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Type: Journal article
Title: Effectiveness of low dose immunotherapy in the treatment of canine atopic dermatitis: a prospective, double-blinded, clinical study
Author: Colombo, S.
Hill, P.
Shaw, D.
Thoday, K.
Citation: Veterinary Dermatology: an international journal, 2005; 16(3):162-170
Publisher: Blackwell Science Ltd
Issue Date: 2005
ISSN: 0959-4493
Statement of
Silvia Colombo, Peter B. Hill, Darren J. Shaw and Keith L. Thoday
Abstract: There are anecdotal reports of increased effectiveness of allergen-specific immunotherapy (ASIT) in dogs with doses of vaccine lower than that recommended by the manufacturers. However, no controlled studies have been carried out. The aim of this prospective, double-blinded study was to evaluate whether induction and maintenance with low dose (LD) ASIT resulted in a different success rate compared with the standard dose (SD). Twenty-seven dogs with confirmed atopic dermatitis were allocated by block randomization to two groups. One group (n = 13) received SD ASIT; the other group (n = 14) received LD ASIT (1/10 of the SD) following the same frequency protocol. Cases were graded at 0, 3, 6 and 9 months for clinical signs using a modified canine atopic dermatitis extent and severity index (mCADESI) and for pruritus using a 0–5 descriptor scale. There were no significant differences between the groups in the pruritus and mCADESI scores (P > 0.155) at the end of the study, and the changes in pruritus (P > 0.920) and mCADESI (P > 0.296) scores from the beginning to the end of the study were similar in both groups. Pruritus scores in both groups did not change during the study (P > 0.052). However, significant reductions in mCADESI scores were seen in both groups (P < 0.032). Six dogs achieved a final pruritus score of 0, six achieved a reduction in pruritus score and 15 did not improve or worsened. There was, therefore, no evidence that LD ASIT is more effective than the standard protocol.
Keywords: Animals
Dermatitis, Atopic
Dog Diseases
Treatment Outcome
Desensitization, Immunologic
Prospective Studies
Double-Blind Method
Description: The definitive version is available at
Rights: © 2005 European Society of Veterinary Dermatology.Copyright © 1999-2010 John Wiley & Sons, Inc.
DOI: 10.1111/j.1365-3164.2005.00453.x
Appears in Collections:Animal and Veterinary Sciences publications
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