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http://hdl.handle.net/2440/62822
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Type: | Journal article |
Title: | Comorbidity of chronic disease and potential treatment conflicts in older people dispensed antidepressants |
Author: | Caughey, G. Roughead, E. Shakib, S. McDermott, R. Vitry, A. Gilbert, A. |
Citation: | Age and Ageing, 2010; 39(4):488-494 |
Publisher: | Oxford Univ Press |
Issue Date: | 2010 |
ISSN: | 0002-0729 1468-2834 |
Department: | Clinical and Experimental Pharmacology |
Statement of Responsibility: | Gillian Elizabeth Caughey, Elizabeth Ellen Roughead, Sepehr Shakib, Robyn A. McDermott, Agnes I. Vitry and Andrew L. Gilbert |
Abstract: | Objectives: the study aimed to examine the prevalence of comorbidity, the prescribing of potentially inappropriate medications and treatment conflicts in a large sample of older people who have been dispensed an antidepressant medicine. Methods: a cross-sectional study of administrative claims data from the Department of Veterans’ Affairs, Australia, 1 April–31 July 2007, of veterans aged ≥65 years was conducted. Comorbidities determined using the pharmaceutical-based comorbidity index, Rx-Risk-V. Concomitant medicines that may be potentially inappropriate for patients with depression and areas of treatment conflicts were determined from Australian clinical guidelines or reference compendia. Results: a total of 39,695 subjects were included, with a median of 5 comorbid conditions (inter-quartile range 3–6). Ninety percent of medicine use was attributed to the treatment of comorbid conditions. Eighty-seven percent of the study cohort was identified as having at least one comorbid condition that may cause a potential treatment conflict when an antidepressant is used. Those conditions of most concern included cardiovascular diseases, anxiety disorders, arthritis or pain management and osteoporosis. Conclusion: we observed a high level of potentially inappropriate prescribing and treatment conflicts that may arise when caring for older patients dispensed an antidepressant with comorbidity. These have the potential to place a large number of older people with depression at increased risk for adverse events. |
Keywords: | comorbidity; antidepressant; depression; chronic disease; elderly |
Rights: | © The Author 2010. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. |
RMID: | 0020101920 |
DOI: | 10.1093/ageing/afq055 |
Appears in Collections: | Pharmacology publications |
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