Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/62910
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Type: Journal article
Title: Effects of metoclopramide on duodenal motility and flow events, glucose absorption, and incretin hormone release in response to intraduodenal glucose infusion
Author: Kuo, P.
Bellon, M.
Wishart, J.
Smout, A.
Holloway, R.
Fraser, R.
Horowitz, M.
Jones, K.
Rayner, C.
Citation: American Journal of Physiology-Gastrointestinal and Liver Physiology, 2010; 299(6):G1326-G1333
Publisher: Amer Physiological Soc
Issue Date: 2010
ISSN: 0193-1857
1522-1547
Statement of
Responsibility: 
Paul Kuo, Max Bellon, Judith Wishart, André J. Smout, Richard H. Holloway, Robert J. L. Fraser, Michael Horowitz, Karen L. Jones, and Christopher K. Rayner
Abstract: The contribution of small intestinal motor activity to nutrient absorption is poorly defined. A reduction in duodenal flow events after hyoscine butylbromide, despite no change in pressure waves, was associated with reduced secretion of the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) and a delay in glucose absorption. The aim of this study was to investigate the effect of metoclopramide on duodenal motility and flow events, incretin hormone secretion, and glucose absorption. Eight healthy volunteers (7 males and 1 female; age 29.8 ± 4.6 yr; body mass index 24.5 ± 0.9 kg/m2) were studied two times in randomized order. A combined manometry and impedance catheter was used to measure pressure waves and flow events in the same region of the duodenum simultaneously. Metoclopramide (10 mg) or control was administered intravenously as a bolus, followed by an intraduodenal glucose infusion for 60 min (3 kcal/min) incorporating the 14C-labeled glucose analog 3-O-methylglucose (3-OMG). We found that metoclopramide was associated with more duodenal pressure waves and propagated pressure sequences than control (P < 0.05 for both) during intraduodenal glucose infusion. However, the number of duodenal flow events, blood glucose concentration, and plasma 3-[14C]OMG activity did not differ between the two study days. Metoclopramide was associated with increased plasma concentrations of GLP-1 (P < 0.05) and GIP (P = 0.07) but lower plasma insulin concentrations (P < 0.05). We concluded that metoclopramide was associated with increased frequency of duodenal pressure waves but no change in duodenal flow events and glucose absorption. Furthermore, GLP-1 and GIP release increased with metoclopramide, but insulin release paradoxically decreased.
Keywords: Duodenum; Humans; Carbon Radioisotopes; Metoclopramide; Gastric Inhibitory Polypeptide; Insulin; 3-O-Methylglucose; Glucose; Blood Glucose; Dopamine Antagonists; Gene Expression Regulation; Gastrointestinal Motility; Peristalsis; Adult; Female; Male; Glucagon-Like Peptide 1; Incretins
Rights: Copyright © 2010 the American Physiological Society
RMID: 0020101675
DOI: 10.1152/ajpgi.00476.2009
Appears in Collections:Medicine publications

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