Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/62994
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Type: Journal article
Title: Effects of nutritional supplementation on the appetite and energy intake responses to IV cholecystokinin in older adults
Author: Tai, K.
Feinle-Bisset, C.
Horowitz, M.
Wishart, J.
Chapman, I.
Citation: Appetite, 2010; 55(3):473-477
Publisher: Elsevier BV
Issue Date: 2010
ISSN: 0195-6663
1095-8304
Statement of
Responsibility: 
Kamilia Tai, Christine Feinle-Bisset, Michael Horowitz, Judith M. Wishart, Ian M. Chapman
Abstract: Human aging is associated with a reduction in appetite and food intake. Increased activity of the satiety hormone, cholecystokinin (CCK), may be partly responsible. This study aimed to determine whether an increase in fat and energy intake modifies the suppressive effects of CCK-8 on appetite and energy intake. Fourteen healthy older adults completed three separate dietary periods, a 14-day and a 7-day normal diet (ND; 8272 ± 480 kJ/day; 35% fat), and a 14-day high-fat diet (HFD; 11,642 ± 414 kJ/day; 43% fat), in randomised order. Immediately following each diet, subjects received, in single-blinded fashion, a 30-min intravenous infusion of either CCK-8 (1.5 ng/kg/min) (ND-CCK, HFD-CCK) or 0.9% saline (ND-SAL), the latter following only ND. Plasma CCK concentrations, appetite responses and energy intake at a buffet meal were determined. Energy intake at the buffet meal was higher on the ND-SAL study day (3349 ± 224 kJ), when compared with either ND-CCK (3023 ± 317 kJ) or HFD-CCK (2905 ± 316 kJ). The suppression of energy intake by CCK-8 infusion did not differ between the two diets. We conclude that suppression of energy intake by exogenous CCK-8 does not appear to be attenuated by incorporation of supplemental high-energy, high-fat drinks in the diet of healthy older adults.
Keywords: Aging; Cholecystokinin; Nutritional supplementation; Fat
Rights: Copyright © 2010 Elsevier Ltd. All rights reserved.
RMID: 0020102856
DOI: 10.1016/j.appet.2010.08.010
Appears in Collections:Medicine publications

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