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dc.contributor.authorSneppen, K.en
dc.contributor.authorPedersen, S.en
dc.contributor.authorKrishna, S.en
dc.contributor.authorDodd, I.en
dc.contributor.authorSemsey, S.en
dc.identifier.citationMBio, 2010; 1(4):1-3en
dc.description.abstractGenes of prokaryotes and Archaea are often organized in cotranscribed groups, or operons. In contrast, eukaryotic genes are generally transcribed independently. Here we show that there is a substantial economic gain for the cell to cotranscribe genes encoding protein complexes because it synchronizes the fluctuations, or noise, in the levels of the different components. This correlation substantially reduces the shortfall in production of the complex. This benefit is relatively large in small cells such as bacterial cells, in which there are few mRNAs and proteins per cell, and is diminished in larger cells such as eukaryotic cells.en
dc.description.statementofresponsibilityKim Sneppen, Steen Pedersen, Sandeep Krishna, Ian Dodd, and Szabolcs Semseyen
dc.publisherAmercian Society for Microbiologyen
dc.rights© 2010 Sneppen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.subjectBacteria; Proteins; Operon; Models, Genetic; Protein Stability; Eukaryotaen
dc.titleEconomy of operon formation: Cotranscription minimizes shortfall in protein complexesen
dc.typeJournal articleen
pubs.library.collectionMolecular and Biomedical Science publicationsen
Appears in Collections:Molecular and Biomedical Science publications

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