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Type: Journal article
Title: Spherical N-carboxyethylchitosan/hydroxyapatite nanoparticles prepared by ionic diffusion process in a controlled manner
Author: Zhu, A.
Lu, Y.
Zhou, Y.
Dai, S.
Citation: Journal of Materials Science: Materials in Medicine, 2010; 21(12):3095-3101
Publisher: Kluwer Academic Publ
Issue Date: 2010
ISSN: 0957-4530
Statement of
Aiping Zhu, Yan Lu, Yao Zhou, Sheng Dai
Abstract: The nanocomposites containing hydroxyapatite (HA) and biomacromolecules have attracted considerable research interest in implants, tissue scaffolds and drug controlled delivery. In this study, the N-carboxyethylchitosan/hydroxyapatite (NCECS/HA) nanoparticles were prepared by the ionic diffusion process in a controlled manner. The crystallization, particle size, size distribution and aggregation morphology of the NCECS/HA nanocomposites were dependent on the mole ratio of the glucosamine unit in NCECS to the Ca(2+). Fourier transform-infrared spectroscopic (FTIR) result indicated that there are chemical bonds formed between NCECS and HA. X-ray diffraction (XRD) analysis showed that the crystallization of HA in NCECS matrix was significantly retarded. Transmission electron microscopy (TEM) results revealed that NCECS/HA nanocomposites have the spherical morphology with the diameter ranging from 10 to 40 nm. The NCECS mineralization is driven by the self-assembly of NCECS and HA. These NCECS/HA nanocomposites have potential applications as the carrier for the controlled delivery of growth factors and drugs.
Keywords: Durapatite
Microscopy, Electron, Transmission
X-Ray Diffraction
Spectroscopy, Fourier Transform Infrared
Tissue Engineering
Phase Transition
Models, Biological
Tissue Scaffolds
Rights: © Springer Science+Business Media, LLC 2010
DOI: 10.1007/s10856-010-4157-7
Grant ID: 08KJA430003
Published version:
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Chemical Engineering publications

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