Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/63200
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dc.contributor.authorHou, C.-
dc.contributor.authorPemberton, A.-
dc.contributor.authorNuttall, T.-
dc.contributor.authorHill, P.-
dc.date.issued2005-
dc.identifier.citationVeterinary Immunology and Immunopathology, 2005; 106(1-2):121-128-
dc.identifier.issn0165-2427-
dc.identifier.issn1873-2534-
dc.identifier.urihttp://hdl.handle.net/2440/63200-
dc.description.abstractIn this study, we used a semi-quantitative electrophoresis and immunoblotting technique to characterise the IgG response to antigens from Dermatophagoides farinae in 20 healthy and 20 atopic dogs. Both groups mounted an IgG response to multiple antigens from the mite. There was no significant difference in the number of bands recognised, or the molecular weights of the bands, between the two groups. The two most obvious bands in both groups were proteins with molecular weights of 98 kDa (likely to be the high molecular weight allergen Der f 15) and 44 kDa, although dogs in both groups recognised a similar pattern of other antigens. The magnitude of the IgG response was greater in the atopic group although this was not statistically significant. The results indicate that the immune system of both healthy and atopic dogs generates an IgG response to multiple antigens from D. farinae. As some of these antigens (such as the 98 and 44 kDa proteins) are also targeted by IgE in atopic dogs, immunoglobulin class switching in response to Th2 cytokines may not be as dominant a process as has been proposed.-
dc.description.statementofresponsibilityChia-Chun Hou, Alan Pemberton, Tim Nuttall, Peter B. Hill-
dc.language.isoen-
dc.publisherElsevier Science BV-
dc.rightsCopyright © 2005 Elsevier B.V. All rights reserved.-
dc.subjectAtopic dermatitis-
dc.subjectDermatophagoides farinae-
dc.subjectIgG-
dc.subjectDogs-
dc.titleIgG responses to antigens from Dermatophagoides farinae in healthy and atopic dogs-
dc.typeJournal article-
dc.identifier.doi10.1016/j.vetimm.2005.01.011-
pubs.publication-statusPublished-
dc.identifier.orcidHill, P. [0000-0002-7449-4897]-
Appears in Collections:Animal and Veterinary Sciences publications
Aurora harvest 5

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