Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/63295
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Type: Journal article
Title: No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency
Author: Vajdic, C.
van Leeuwen, M.
Turner, J.
McDonald, A.
Webster, A.
McDonald, S.
Chapman, J.
Kaldor, J.
Grulich, A.
Citation: International Journal of Cancer, 2010; 127(11):2732-2735
Publisher: Wiley-liss
Issue Date: 2010
ISSN: 0020-7136
1097-0215
Statement of
Responsibility: 
Claire M. Vajdic, Marina T. van Leeuwen, Jennifer J. Turner, Ann M. McDonald, Angela C. Webster, Stephen P. McDonald, Jeremy R. Chapman, John M. Kaldor and Andrew E. Grulich
Abstract: Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human immunodeficiency virus (HIV) infection 1982-2004 (n = 17,175). National, population-based registries were linked and standardized incidence ratios (SIRs) were computed for each cohort and lymphoma subtype. Risk of diffuse large B-cell lymphoma was significantly increased after transplantation (SIR 17.83, 95% CI: 13.61-22.95) and after HIV infection (SIR 58.81, 95% CI: 52.59-65.56). Rates of follicular lymphoma (FL) were neither significantly increased nor decreased in transplant recipients (SIR 0.82, 95% CI: 0.10-2.96) and in people with HIV (SIR 1.25, 95% CI: 0.41-2.91). The findings argue against an infectious or other immunodeficiency-related etiology for FL and clearly differentiate it from diffuse large B-cell lymphoma.
Keywords: non-Hodgkin lymphoma; incidence; HIV; transplantation; immunodeficiency
Rights: Copyright © 2010 UICC
RMID: 0020103162
DOI: 10.1002/ijc.25272
Grant ID: http://purl.org/au-research/grants/nhmrc/401131
http://purl.org/au-research/grants/nhmrc/568727
http://purl.org/au-research/grants/nhmrc/568819
http://purl.org/au-research/grants/nhmrc/510346
Appears in Collections:Public Health publications

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