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https://hdl.handle.net/2440/63295
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Type: | Journal article |
Title: | No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency |
Author: | Vajdic, C. van Leeuwen, M. Turner, J. McDonald, A. Webster, A. McDonald, S. Chapman, J. Kaldor, J. Grulich, A. |
Citation: | International Journal of Cancer, 2010; 127(11):2732-2735 |
Publisher: | Wiley-liss |
Issue Date: | 2010 |
ISSN: | 0020-7136 1097-0215 |
Statement of Responsibility: | Claire M. Vajdic, Marina T. van Leeuwen, Jennifer J. Turner, Ann M. McDonald, Angela C. Webster, Stephen P. McDonald, Jeremy R. Chapman, John M. Kaldor and Andrew E. Grulich |
Abstract: | Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human immunodeficiency virus (HIV) infection 1982-2004 (n = 17,175). National, population-based registries were linked and standardized incidence ratios (SIRs) were computed for each cohort and lymphoma subtype. Risk of diffuse large B-cell lymphoma was significantly increased after transplantation (SIR 17.83, 95% CI: 13.61-22.95) and after HIV infection (SIR 58.81, 95% CI: 52.59-65.56). Rates of follicular lymphoma (FL) were neither significantly increased nor decreased in transplant recipients (SIR 0.82, 95% CI: 0.10-2.96) and in people with HIV (SIR 1.25, 95% CI: 0.41-2.91). The findings argue against an infectious or other immunodeficiency-related etiology for FL and clearly differentiate it from diffuse large B-cell lymphoma. |
Keywords: | non-Hodgkin lymphoma incidence HIV transplantation immunodeficiency |
Rights: | Copyright © 2010 UICC |
DOI: | 10.1002/ijc.25272 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/401131 http://purl.org/au-research/grants/nhmrc/568727 http://purl.org/au-research/grants/nhmrc/568819 http://purl.org/au-research/grants/nhmrc/510346 |
Published version: | http://dx.doi.org/10.1002/ijc.25272 |
Appears in Collections: | Aurora harvest Public Health publications |
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