Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/63496
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dc.contributor.authorStevens, J.en
dc.contributor.authorGilja, O.en
dc.contributor.authorGentilcore, D.en
dc.contributor.authorHausken, T.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorJones, K.en
dc.date.issued2011en
dc.identifier.citationNeurogastroenterology and Motility, 2011; 23(3):220-e114en
dc.identifier.issn1350-1925en
dc.identifier.issn1365-2982en
dc.identifier.urihttp://hdl.handle.net/2440/63496-
dc.description.abstractBACKGROUND: Gastric emptying (GE) is delayed in 30-50% of patients with longstanding diabetes. Scintigraphy represents the 'gold standard' for measurement of GE, but is associated with a radiation burden. Three-dimensional (3D) ultrasonography has recently been demonstrated to provide a valid measure of liquid GE in healthy subjects; however, the technique has not been validated in patients with gastroparesis. The primary aim of this study was to compare measurements of GE of a high-nutrient glucose drink by 3D ultrasonography and scintigraphy in diabetic gastroparesis. METHODS: Ten patients (eight type 1, two type 2, 6M, 4F, aged 46.1 ± 4.5 years, BMI 29.1 ± 1.6 kg m(-2), duration 19.6 ± 3.3 years) with diabetic gastroparesis [defined as retention at 100 min of solid (100 g minced beef) ≥ 61% and/or 50% emptying time (T50) of liquid (150 mL 10% dextrose) ≥ 31 min], were studied. Concurrent measurements of GE by scintigraphy and 3D ultrasonography were performed following ingestion of 75 g glucose in 300 mL water labeled with 20 MBq (99m) Tc-sulfur colloid. KEY RESULTS: There was no significant difference in GE between the two techniques (T50s: scintigraphy - 103.3 ± 10.0 min VS 3D ultrasonography - 98.8 ± 10.4 min; P = 0.60). There was a significant correlation between scintigraphic and ultrasonographic T50s (r = 0.67, P = 0.03). The limits of agreement for the T50s were -57.22 min and +48.22 min (mean difference -4.5 min). Blood glucose after the drink was greater when GE was relatively more rapid (e.g. at t = 60 min; scintigraphy: r = -0.65, P = 0.04; 3D ultrasonography: r = -0.78, P = 0.008). CONCLUSIONS & INFERENCES: Three-dimensional ultrasonography appears to provide a valid, and non-invasive, measure of GE of high-nutrient liquids in diabetic gastroparesis.en
dc.description.statementofresponsibilityJ. E. Stevens, O. H. Gilja, D. Gentilcore, T. Hausken, M. Horowitz & K. L. Jonesen
dc.language.isoenen
dc.publisherBlackwell Publishing Ltden
dc.rights© 2010 Blackwell Publishing Ltd.en
dc.subjectdiabetes; gastric emptying; gastrointestinal ultrasound; gastroparesis; ultrasonography.en
dc.titleMeasurement of gastric emptying of a high-nutrient liquid by 3D ultrasonography in diabetic gastroparesisen
dc.typeJournal articleen
dc.identifier.rmid0020103242en
dc.identifier.doi10.1111/j.1365-2982.2010.01630.xen
dc.identifier.pubid32121-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
Appears in Collections:Medicine publications

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