Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/63603
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Type: Journal article
Title: Tumour necrosis factor inhibitors and risk of serious infection in rheumatoid arthritis
Author: Katikireddi, V.
Whittle, S.
Hill, C.
Citation: International Journal of Rheumatic Diseases, 2010; 13(1):12-26
Publisher: Wiley-Blackwell Publishing Asia
Issue Date: 2010
ISSN: 1756-1841
1756-185X
Statement of
Responsibility: 
Veera S. Katikireddi, Samuel L. Whittle and Catherine L. Hill
Abstract: Tumour necrosis factor inhibitors have demonstrated significant clinical and radiological benefits in rheumatoid arthritis (RA). However, they have important adverse effects including an association with infection. Results from current studies, including meta-analyses of randomized controlled trials and observational studies, are conflicting regarding the risk of serious infection in RA patients treated with TNF inhibitors. The majority of data suggest an increased risk, in particular of respiratory, skin and soft tissue infections, including tuberculosis. This increased risk of tuberculosis is of particular concern in the APLAR region. However, adverse event analysis remains a difficult area to study and decisions regarding initiation of TNF inhibitors must be made on a case-by-case basis after carefully considering the risks and benefits.
Keywords: adalimumab; etanercept; infection; infliximab; rheumatoid arthritis; tumour necrosis factor inhibitors
Rights: © Asia Pacific League of Associations for Rheumatology
RMID: 0020101978
DOI: 10.1111/j.1756-185X.2009.01457.x
Appears in Collections:Medicine publications

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