Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/63603
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dc.contributor.authorKatikireddi, V.en
dc.contributor.authorWhittle, S.en
dc.contributor.authorHill, C.en
dc.date.issued2010en
dc.identifier.citationInternational Journal of Rheumatic Diseases, 2010; 13(1):12-26en
dc.identifier.issn1756-1841en
dc.identifier.issn1756-185Xen
dc.identifier.urihttp://hdl.handle.net/2440/63603-
dc.description.abstractTumour necrosis factor inhibitors have demonstrated significant clinical and radiological benefits in rheumatoid arthritis (RA). However, they have important adverse effects including an association with infection. Results from current studies, including meta-analyses of randomized controlled trials and observational studies, are conflicting regarding the risk of serious infection in RA patients treated with TNF inhibitors. The majority of data suggest an increased risk, in particular of respiratory, skin and soft tissue infections, including tuberculosis. This increased risk of tuberculosis is of particular concern in the APLAR region. However, adverse event analysis remains a difficult area to study and decisions regarding initiation of TNF inhibitors must be made on a case-by-case basis after carefully considering the risks and benefits.en
dc.description.statementofresponsibilityVeera S. Katikireddi, Samuel L. Whittle and Catherine L. Hillen
dc.language.isoenen
dc.publisherWiley-Blackwell Publishing Asiaen
dc.rights© Asia Pacific League of Associations for Rheumatologyen
dc.subjectadalimumab; etanercept; infection; infliximab; rheumatoid arthritis; tumour necrosis factor inhibitorsen
dc.titleTumour necrosis factor inhibitors and risk of serious infection in rheumatoid arthritisen
dc.typeJournal articleen
dc.identifier.rmid0020101978en
dc.identifier.doi10.1111/j.1756-185X.2009.01457.xen
dc.identifier.pubid32728-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidWhittle, S. [0000-0001-7417-7691]en
dc.identifier.orcidHill, C. [0000-0001-8289-4922]en
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