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|Title:||Cerebral function in posttraumatic stress disorder during verbal working memory updating: A positron emission tomography study|
|Citation:||Biological Psychiatry, 2003; 53(6):474-481|
|Publisher:||Elsevier Science Inc|
|C. Richard Clark, Alexander C McFarlane, Philip Morris, Darren L Weber, Cynon Sonkkilla, Marnie Shaw, Jackie Marcina, H.J Tochon-Danguy and Gary F Egan|
|Abstract:||Background This study examined cerebral function in posttraumatic stress disorder (PTSD) during the updating of working memory to trauma-neutral, verbal information. Methods Ten PTSD and matched control subjects completed a visuoverbal target detection task involving continuous updating (Variable target condition) or no updating (Fixed target condition) of target identity, with updating activity estimated by condition comparison. Results Normal updating activity using this paradigm involved bilateral activation of the dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobe. The PTSD group lacked this activation in the left hemisphere and was significantly different from control subjects in this regard, but showed additional activation in the superior parietal lobe, bilaterally. Conclusions The pattern of parietal activation suggests a dependence on visuospatial coding for working memory representation of trauma-neutral, verbal information. Group differences in the relative involvement of the DLPFC indicate less dependence in PTSD on the executive role normally attributed to the left DLPFC for monitoring and manipulation of working memory content in posterior regions of the brain.|
|Keywords:||Posttraumatic stress disorder; working memory; positron emission tomography; frontal-parietal axis; cortical networks|
|Description:||Copyright © 2002 Society of Biological Psychiatry Published by Elsevier Inc.|
|Appears in Collections:||Psychiatry publications|
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