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|Title:||IL-6, IL-8 and IL-10 levels in healthy weight and overweight children|
|Citation:||Hormone Research in Paediatrics: from developmental endoctrinology to clinical research, 2010; 73(2):128-134|
|Publisher:||S Karger AG|
|Charmaine S. Tam, Sarah P. Garnett, Christopher T. Cowell, Leonie K. Heilbronn, Jennifer W. Lee, Melanie Wong, Louise A. Baur|
|Abstract:||In adults, studies have shown that obesity is a chronic low-grade inflammatory state characterized by altered levels of cytokines. Studies in children have mainly focused on C-reactive protein and adiponectin, and there is limited data for other inflammatory markers in healthy weight and overweight children. The aim of this study was to measure IL-6, IL-8 and IL-10 levels in healthy normal weight and overweight children at 8 and 15 years.118 normal weight and overweight children (59 boys) from the Nepean longitudinal study were recruited at age 8 years and followed up at 15 years. Serum IL-6, IL-8 and IL-10 levels were measured at both time-points.At 8 years, we found no significant differences in cytokine levels between normal weight and overweight (owt)/obese (ob) groups. However, at 15 years, owt/ob girls (n = 23) had higher levels of IL-6 (p = 0.04), IL-8 (p = 0.04) and IL-10 (p = 0.03) compared to normal weight girls (n = 36), even after adjustment for puberty; no differences were seen in boys.The effects of obesity on IL-6, IL-8 and IL-10 levels vary with age and sex, with owt/ob girls at 15 years showing raised IL-6, IL-8 and IL-10 levels compared to healthy weight girls.|
|Keywords:||Cytokine; Inflammation; Obesity; Children; Interleukin-8|
|Rights:||Copyright © 2010 S. Karger AG, Basel|
|Appears in Collections:||Medicine publications|
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