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https://hdl.handle.net/2440/63780
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dc.contributor.author | Tam, C. | - |
dc.contributor.author | Garnett, S. | - |
dc.contributor.author | Cowell, C. | - |
dc.contributor.author | Heilbronn, L. | - |
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Wong, M. | - |
dc.contributor.author | Baur, L. | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Hormone Research in Paediatrics: from developmental endocrinology to clinical research, 2010; 73(2):128-134 | - |
dc.identifier.issn | 1663-2818 | - |
dc.identifier.issn | 1663-2826 | - |
dc.identifier.uri | http://hdl.handle.net/2440/63780 | - |
dc.description.abstract | <h4>Background/aim</h4>In adults, studies have shown that obesity is a chronic low-grade inflammatory state characterized by altered levels of cytokines. Studies in children have mainly focused on C-reactive protein and adiponectin, and there is limited data for other inflammatory markers in healthy weight and overweight children. The aim of this study was to measure IL-6, IL-8 and IL-10 levels in healthy normal weight and overweight children at 8 and 15 years.<h4>Methods</h4>118 normal weight and overweight children (59 boys) from the Nepean longitudinal study were recruited at age 8 years and followed up at 15 years. Serum IL-6, IL-8 and IL-10 levels were measured at both time-points.<h4>Results</h4>At 8 years, we found no significant differences in cytokine levels between normal weight and overweight (owt)/obese (ob) groups. However, at 15 years, owt/ob girls (n = 23) had higher levels of IL-6 (p = 0.04), IL-8 (p = 0.04) and IL-10 (p = 0.03) compared to normal weight girls (n = 36), even after adjustment for puberty; no differences were seen in boys.<h4>Conclusion</h4>The effects of obesity on IL-6, IL-8 and IL-10 levels vary with age and sex, with owt/ob girls at 15 years showing raised IL-6, IL-8 and IL-10 levels compared to healthy weight girls. | - |
dc.description.statementofresponsibility | Charmaine S. Tam, Sarah P. Garnett, Christopher T. Cowell, Leonie K. Heilbronn, Jennifer W. Lee, Melanie Wong, Louise A. Baur | - |
dc.language.iso | en | - |
dc.publisher | S Karger AG | - |
dc.rights | Copyright © 2010 S. Karger AG, Basel | - |
dc.source.uri | http://dx.doi.org/10.1159/000277632 | - |
dc.subject | Cytokine | - |
dc.subject | Inflammation | - |
dc.subject | Obesity | - |
dc.subject | Children | - |
dc.subject | Interleukin-8 | - |
dc.title | IL-6, IL-8 and IL-10 levels in healthy weight and overweight children | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1159/000277632 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/206501 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/481354 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Heilbronn, L. [0000-0003-2106-7303] | - |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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