Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/63807
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Type: Journal article
Title: Lacrimal gland involvement in lymphomatoid granulomatosis and review of the literature
Author: Pradeep, T.
Cannon, P.
Dodd, T.
Selva-Nayagam, D.
Citation: Journal of Ophthalmology, 2010; online:1-6
Publisher: Hindawi Publishing Corporation
Issue Date: 2010
ISSN: 2090-004X
2090-0058
Statement of
Responsibility: 
Thanuja Gopal Pradeep, Paul Cannon, Thomas Dodd, and Dinesh Selva
Abstract: Objective. To describe the clinicoradiological and histopathological findings in a case of lacrimal gland enlargement secondary to lymphomatoid granulomatosis (LG) and to review the literature. Design. Case report and systematic literature review. Methods. A 75-year-old woman presented with right ptosis. Computerised tomography showed lacrimal gland enlargement, and biopsy done was inconclusive. She subsequently developed pulmonary symptoms and underwent transbronchial biopsy that was diagnosed as LG. PubMed andOVID databases were searched using the term “orbit/eye involvement in lymphomatoid granulomatosis”. Articles that predated the databases were gathered from current references. Results. The patient underwent lacrimal gland biopsy which revealed necrotic and inflamed tissue with no further categorisation but transbronchial biopsy helped in establishing the diagnosis of LG. On initiation of prednisolone and cyclophosphamide, her orbital lesion resolved but the patient died following massive pulmonary hemorrhage within amonth of diagnosis. Conclusion. Ophthalmic involvement in LG is very rare. Varied presentations are due to central nervous system involvement, vasculitis, or infiltration of ocular or orbital structures. LG is an angiocentric and angiodestructive granulomatous disorder and can involve any tissue, thus accounting for the variable presentations reported in literature.
Rights: Copyright © 2010 Thanuja Gopal Pradeep et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0020105215
DOI: 10.1155/2010/358121
Appears in Collections:Opthalmology & Visual Sciences publications

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