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Type: Journal article
Title: Risk of cancer in patients with biopsy-proven giant cell arteritis
Author: Hill, C.
Cole, A.
Rischmueller, M.
Dodd, T.
Coleman, M.
Tucker, G.
Roberts-Thomson, P.
Citation: Rheumatology, 2010; 49(4):756-759
Publisher: Oxford Univ Press
Issue Date: 2010
ISSN: 1462-0324
1462-0332
Statement of
Responsibility: 
Catherine L. Hill, Antonia Cole, Maureen Rischmueller, Thomas Dodd, Mark Coleman, Graeme Tucker and Peter Roberts-Thomson
Abstract: Objective. Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study of the risk of cancer in patients with biopsy-proven GCA. Methods. Patients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies from the major pathology laboratories in South Australia (SA). All subjects with biopsy-proven GCA were linked to the SA Cancer Registry to identify cases of cancer until 31 December 2006. Standardized incidence ratios (SIRs) for cancer were determined using the age- and gender-specific rates for SA. Results. There were 226 cases of biopsy-proven GCA (163 females and 63 males). Thirty-one cases were diagnosed with cancer, following the diagnosis of biopsy-proven GCA. There was no increased risk of cancer among those with biopsy-proven GCA, following the diagnosis of GCA compared with the general population (SIR 1.2; 95% CI 0.8, 1.6). Conclusion. This cohort study did not demonstrate any increased risk for malignancy in subjects with biopsy-proven GCA.
Keywords: Giant cell arteritis; Malignancy; Epidemiology; Population.
Rights: © The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
RMID: 0020095893
DOI: 10.1093/rheumatology/kep409
Appears in Collections:Medicine publications

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