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Type: Journal article
Title: Surface contamination of cytotoxic drug 5-fluorouracil (5-FU) and decontamination
Author: Tkaczuk, M.
Lee, S.
Jankewicz, G.
Ambados, F.
Citation: Journal of Health, Safety and Environment, 2010; 26(2):171-181
Publisher: CCH Australia Ltd
Issue Date: 2010
ISSN: 1837-9362
Statement of
M. Tkaczuk, S.-G. Lee, G. Jankewicz and F. Ambados
Abstract: Wipe sampling of surfaces was carried out in the pharmacy compounding area and inpatient and outpatient wards of a South Australian public hospital that administered cytotoxic drugs to clients. 5-flourouracil (5-FU) was chosen as an indicator cytotoxic drug, as it was commonly used and administered in these areas of the hospital. Analysis of wipe samples indicated that most surfaces in the pharmacy compounding area and inpatient and outpatient wards were contaminated with 5-FU. These surfaces included phones, keyboards, chair armrests, benchtops, door handles, PC mouses and fridge doors. Five different decontaminant agents were tested and only one (a 0.5% weight per volume sodium hypochlorite solution) was found to be effective as a cleaning agent that rapidly breaks down 5-FU and also kills bacteria. Sampling of surfaces for 5-FU contamination post-cleaning with 0.5% w/v sodium hypochlorite found that this cleaning agent was effective in decontaminating the 5-FU contaminated surfaces.
Rights: © Copyright 2011 Elsevier B.V., All rights reserved.
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