Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/6444
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Type: Journal article
Title: Evaluation of dexfenfluramine in a weight loss program for obese infertile women.
Author: Galletly, C.
Clark, A.
Tomlinson, L.
Citation: International Journal of Eating Disorders, 1996; 19(2):209-212
Publisher: Wiley
Issue Date: 1996
ISSN: 0276-3478
1098-108X
Statement of
Responsibility: 
Cherrie Galletly, Anne Clark, Liza Tomlinson
Abstract: <h4>Objective</h4>To evaluate the usefulness of dexfenfluramine as an adjunct to a group treatment program for obese infertile women.<h4>Method</h4>Twenty-one obese infertile women were referred by the Reproductive Medicine Unit. They attended a 24-week group program which included exercise and educational sessions. Dexfenfluramine and placebo were given, each for 12 weeks, in a double-blind crossover design.<h4>Results</h4>Dexfenfluramine treatment was not associated with greater loss of weight. The mean weight loss during dexfenfluramine treatment was 3.21 kg (SD 3.09) and during placebo was 3.31 kg (SD 3.15). Self-esteem, anxiety, and depression ratings all improved significantly over the 24 weeks.<h4>Discussion</h4>The group treatment program appeared to be equally effective with or without dexfenfluramine. Previous studies have found dexfenfluramine to be effective in combination with individual treatment, but it has not previously been evaluated as an adjunct to group treatment. It is unclear whether dexfenfluramine may be less effective in combination with group treatment programs, or whether its usefulness is restricted in this particular population of obese patients. No differences were found associated with the order in which active and placebo treatments were given. Patients showed improvement in self-esteem and reduction in depression and anxiety, but dexfenfluramine treatment was not associated with any difference in these measures, compared to placebo.
Keywords: Humans
Infertility, Female
Obesity
Weight Loss
Fenfluramine
Appetite Depressants
Treatment Outcome
Combined Modality Therapy
Exercise
Double-Blind Method
Psychotherapy, Group
Adult
Female
DOI: 10.1002/(SICI)1098-108X(199603)19:2<209::AID-EAT12>3.0.CO;2-P
Appears in Collections:Aurora harvest
Psychiatry publications

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