Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/64912
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: A three-way interplay of DR4, autoantibodies and synovitis in biopsy-proven idiopathic inflammatory myositis
Author: Limaye, V.
Lester, S.
Bardy, P.
Thompson, P.
Cox, S.
Blumbergs, P.
Roberts-Thomson, P.
Citation: Rheumatology International, 2012; 32(3):611-619
Publisher: Springer-Verlag
Issue Date: 2012
ISSN: 0172-8172
1437-160X
Statement of
Responsibility: 
Vidya S. Limaye, Sue Lester, Peter Bardy, Philip Thompson, Sally Cox, Peter Blumbergs, Peter Roberts-Thomson
Abstract: The aim of this study was to determine the HLA and autoantibody associations of patients with histologically confirmed idiopathic inflammatory myositis (IIM). Serum and DNA were archived from South Australian patients with biopsy-proven dermatomyositis (DM), polymyositis (PM) and inclusion body myositis (IBM). HLA typing for Class I and II alleles was performed by serology and DNA-based technology, respectively, for 133 myositis patients and 166 Caucasian population-based controls. Myositis-specific and myositis-associated autoantibodies were detected by line immunoblot. All alleles of the 8.1AH were associated with myositis susceptibility. The B8-DR3 haplotype fragment conferred the strongest susceptibility (OR 2.9, 95% CI 1.8–4.6), and the B-DR region of other ancestral haplotypes was associated with myositis subgroups. Autoantibodies were present in 42/130 (32%) IIM patients and were more frequent in DM (11/17, 65%) than PM (23/70, 33%) or IBM (8/43, 19%), P = 0.002. Autoantibodies were associated with DRB1*03 (P = 0.0005) but also with DRB1*04 (P = 0.004). The frequency of autoantibodies in the three myositis subgroups mirrored the frequency of DR4. Polyarthralgia (±synovitis) was more common in DM/PM (30/76, 39%) than IBM (3/32, 9%), P = 0.004, and there was a strong ordinal association between the prevalence of autoantibodies and polyarthralgia ± synovitis (proportional OR = 5.5, 95% CI 2.3–13.7, P = 0.0004). The central MHC region confers the strongest susceptibility for IIM and also modulates disease phenotype. Our findings reveal a novel association of autoantibodies with DR4 and with arthralgia/synovitis in IIM and raise the possibility of a genetically (DR4) determined citrullination of myositis autoantigens expressed in muscle and synovium.
Keywords: Inflammatory myositis; Polymyositis; Dermatomyositis; Inclusion body myositis; Autoantibodies; HLA; Muscle histology
Rights: © Springer-Verlag 2010
RMID: 0020104868
DOI: 10.1007/s00296-010-1637-5
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.