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Type: Journal article
Title: The effect of recombinant follicle stimulating hormone (Gonal-F) on endogenous luteinizing hormone secretion in women
Author: Hull, M.
Livesey, J.
Evans, J.
Benny, P.
Citation: Human Reproduction, 1998; 13(5):1139-1143
Publisher: Oxford University Press
Issue Date: 1998
ISSN: 0268-1161
Statement of
M. L. Hull, J. H. Livesey, J. J. Evans and P. S. Benny
Abstract: Parenteral administration of follicle stimulating hormone (FSH) has been shown to lower luteinizing hormone (LH) concentrations in women undergoing ovulation induction. This study was designed to explore the physiological mechanism of this effect. Seven healthy women were recruited into a double-blind placebo-controlled study. LH secretion, after the administration of variable i.v. boluses (37.5, 75 and 150 IU) of recombinant FSH (Gonal-F), was evaluated. LH was measured at 10 min intervals for 2 h before and 4 h after the FSH/placebo infusion. LH pulse frequency and amplitude were evaluated and there was no significant difference between control and trial cycles for each subject. A linear regression analysis revealed that in the group receiving 150 IU FSH, the mean plasma LH concentration decreased significantly due to a reduction tonic LH secretion. This could be a result of the suppression of secretion or an alteration of clearance. This decrease was not seen in the other dosage groups, revealing that above a dosage threshold, FSH reduced non-pulsatile LH secretion. Therefore the effect of FSH in this study exposed the likely presence of two components of LH concentration: an FSH-sensitive, non-pulsatile tonic secretion and a gonadotrophin- releasing hormone-stimulated, pulsatile release that is unaffected by FSH. Although an indirect effect involving ovarian regulation is not excluded, the rapidity of the effect suggests that FSH acts directly on the pituitary gland.
Keywords: anterior pituitary
follicle stimulating hormone
gonadotrophin-releasing hormone
gonadotrophin surge attenuating factor
luteinizing hormone
Rights: © European Society for Human Reproduction and Embryology
DOI: 10.1093/humrep/13.5.1139
Appears in Collections:Aurora harvest 5
Obstetrics and Gynaecology publications

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