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Type: Journal article
Title: Trade-Off between Iron Uptake and Protection against Oxidative Stress: Deletion of cueO Promotes Uropathogenic Escherichia coli Virulence in a Mouse Model of Urinary Tract Infection
Author: Tree, J.
Ulett, G.
Ong, C.
Trott, D.
McEwan, A.
Schembri, M.
Citation: Journal of Bacteriology, 2008; 190(20):6909-6912
Publisher: Amer Soc Microbiology
Issue Date: 2008
ISSN: 0021-9193
Statement of
Jai J. Tree, Glen C. Ulett, Cheryl-Lynn Y. Ong, Darren J. Trott, Alastair G. McEwan, and Mark A. Schembri
Abstract: The periplasmic multicopper oxidase (CueO) is involved in copper homeostasis and protection against oxidative stress. Here, we show that the deletion of cueO in uropathogenic Escherichia coli increases its colonization of the urinary tract despite its increased sensitivity to hydrogen peroxide. The cueO deletion mutant accumulated iron with increased efficiency compared to its parent strain; this may account for its advantage in the iron-limited environment of the urinary tract.
Keywords: Urine; Animals; Mice, Inbred C57BL; Mice; Escherichia coli; Urinary Tract Infections; Hydrogen Peroxide; Iron; Oxidoreductases; Escherichia coli Proteins; Anti-Bacterial Agents; Virulence; Gene Deletion; Oxidative Stress; Female; Microbial Viability; Urinary Bladder
Rights: Copyright © 2008, American Society for Microbiology. All Rights Reserved.
RMID: 0020106742
DOI: 10.1128/JB.00451-08
Appears in Collections:Agriculture, Food and Wine publications

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