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Type: Journal article
Title: Serotonin receptor 1A-1019C/G variant: impact on antidepressant pharmacoresponse in melancholic depression?
Author: Baune, B.
Hohoff, C.
Roehrs, T.
Deckert, J.
Arolt, V.
Domschke, K.
Citation: Neuroscience Letters, 2008; 436(2):111-115
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2008
ISSN: 0304-3940
Statement of
B.T. Baune, C. Hohoff, T. Roehrs, J. Deckert, V. Arolt, K. Domschke
Abstract: Previous studies on the effects of serotonin receptor 1A (5-HT1A) gene variation on treatment response in depression revealed inconsistent results with studies pointing towards a detrimental influence of the 5-HT1A-1019G allele on antidepressant treatment response, while others did not discern any involvement of 5-HT1A variants. In order to further delineate the impact of 5-HT1A gene variation on pharmacoresponse in depression over 6 weeks of antidepressant treatment, the influence of the 5-HT1A-1019C/G (rs6295) polymorphism was investigated in 340 Caucasian patients with a Major Depressive Episode (DSM-IV) with particular attention to the subtype of depression (major depression and melancholic depression). Antidepressant treatment response across 5-HT1A-1019C/G genotype groups showed no differences in either Major Depressive Episode or major depression between genotype groups, whereas stratification for the melancholic subtype of depression revealed a significantly worse treatment response as conferred by the -1019CC genotype (p=0.02). The poorer treatment response in melancholic depression could first be detected in week 2 (p=0.03), continuing until week 6 and showing a maximum effect in week 3 (p=0.01). The present study adds to the clarification of the role of 5-HT1A variation in treatment response in major depression by providing preliminary support for poor treatment response mediated by the 5-HT1A-1019C allele repressing 5-HT1A activity specifically in the melancholic subtype of depression.
Keywords: Major Depressive Episode
Melancholic depression
Serotonin receptor
Rights: © 2008 Elsevier Ireland Ltd. All rights reserved.
DOI: 10.1016/j.neulet.2008.03.001
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Psychiatry publications

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