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Type: Journal article
Title: Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression
Author: Domschke, K.
Dannlowski, U.
Ohrmann, P.
Lawford, B.
Bauer, J.
Kugel, H.
Heindel, W.
Young, R.
Morris, P.
Arolt, V.
Deckert, J.
Suslow, T.
Baune, B.
Citation: European Neuropsychopharmacology, 2008; 18(10):751-759
Publisher: Elsevier Science BV
Issue Date: 2008
ISSN: 0924-977X
Statement of
Katharina Domschke, Udo Dannlowski, Patricia Ohrmann, Bruce Lawford, Jochen Bauer, Harald Kugel, Walter Heindel, Ross Young, Phillip Morris, Volker Arolt, Jürgen Deckert, Thomas Suslow, Bernhard T. Baune
Abstract: The endocannabinoid system has been implicated in the pathogenesis of depression and anxiety, the mediation of antidepressant drug effects in animal models and the neurobiology of emotion processing in healthy volunteers. Therefore, the impact of cannabinoid receptor 1 gene (CNR1) variants rs1049353 and rs12720071 on antidepressant treatment response was evaluated in 256 Caucasian patients with Major Depression. A subsample of 33 depressed patients was additionally scanned by fMRI under visual presentation of emotional faces. The CNR1 rs1049353 G allele conferred an increased risk of antidepressant treatment resistance, particularly in female patients with high comorbid anxiety. CNR1 rs1049353 G allele carriers also demonstrated weaker bilateral amygdala, putamen and pallidum activity as well as left lateralized caudate and thalamus activity in response to masked happy faces. This analysis provides preliminary support for a role of CNR1 gene variation in depression and anxiety, potentially mediated by subcortical hypo-responsiveness to social reward stimuli.
Keywords: Depression
Endocannabinoid system
Treatment response
Rights: © 2008 Elsevier B.V. and ECNP. All rights reserved.
DOI: 10.1016/j.euroneuro.2008.05.003
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Psychiatry publications

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