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Type: Journal article
Title: Medical Comorbidity Affects Antidepressant Treatment Response in Patients with Melancholic Depression
Author: Pohle, K.
Domschke, K.
Roehrs, T.
Arolt, V.
Baune, B.
Citation: Psychotherapy and Psychosomatics, 2009; 78(6):359-363
Publisher: Karger
Issue Date: 2009
ISSN: 0033-3190
Statement of
K. Pohle, K. Domschke, T. Roehrs, V. Arolt, B.T. Baune
Abstract: <h4>Background</h4>This study aimed at the impact of medical comorbidity (MC) on response to antidepressant treatment over 6 weeks in diagnostic subtypes of patients with major depressive episode (MDE).<h4>Methods</h4>In a clinical sample of 241 admitted patients with MDE, MC was assessed by medical specialists and weekly response to antidepressant treatment was assessed with the Hamilton Depression Scale (HAM-D 21).<h4>Results</h4>Over 6 weeks of treatment, patients with melancholic depression and MC had poorer treatment response on the HAM-D scale and a worse functional outcome (GAF) as opposed to their counterparts without MC, which was first detected after 4 weeks of treatment (p = 0.02). More specifically, subjects with melancholic depression and cardiovascular or endocrinological MC showed significantly poorer treatment response over 6 weeks. Interestingly, these effects were not related to various antidepressant treatment regimens.<h4>Conclusions</h4>MC has a negative impact on treatment response in patients with melancholic depression.
Keywords: Medical comorbidity
Subtypes of depression
Treatment response
Rights: © 2009 S. Karger AG, Basel
DOI: 10.1159/000235975
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Psychiatry publications

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