Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/65787
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Type: Journal article
Title: Regulation of sphingosine kinase and sphingolipid signaling
Author: Pitson, S.
Citation: Trends in Biochemical Sciences, 2011; 36(2):97-107
Publisher: Elsevier Science London
Issue Date: 2011
ISSN: 0968-0004
1362-4326
Statement of
Responsibility: 
Stuart M. Pitson
Abstract: Bioactive sphingolipids, including ceramide, sphingosine and sphingosine 1-phosphate are important regulators of many cellular processes, including cell survival, proliferation, differentiation, migration and immune responses. Although the levels of these bioactive sphingolipids are regulated by complex pathways subject to spatial and temporal control, the sphingosine kinases have emerged as critical central regulators of this system and, as a consequence, they have received substantial recent attention as potential therapeutic targets for cancer and a range of other conditions. Deciphering the molecular mechanisms that regulate both the activity and subcellular localization of these enzymes is vital for understanding the control of bioactive sphingolipid generation and action, and has clear implications for therapeutic strategies targeting these enzymes.
Keywords: Cells
Animals
Humans
Isoenzymes
Phosphotransferases (Alcohol Group Acceptor)
Sphingolipids
Signal Transduction
Rights: Copyright © 2011 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.tibs.2010.08.001
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/405916/description#description
Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

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