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Type: Journal article
Title: Effects of Clozapine for Non-Treatment-Resistant Patients with Schizophrenia
Author: Galletly, C.
Clark, C.
McFarlane, A.
Weber, D.
Citation: Psychiatric Services, 1999; 50(1):101-103
Issue Date: 1999
ISSN: 1075-2730
Abstract: Clozapine is generally used for patients meeting criteria for treatment resistance. In this study clozapine was given to 19 patients with schizophrenia who did not meet these criteria and whose symptoms were mild to moderate in severity. Clozapine was associated with significant improvement in positive and negative symptoms and quality of life. A more modest improvement on a range of tests of cognitive functioning was also noted. These results suggest that consideration should be given to broadening the usual criteria for patients' eligibility for clozapine treatment.
Keywords: Humans; Clozapine; Antipsychotic Agents; Treatment Outcome; Drug Administration Schedule; Schizophrenia; Psychiatric Status Rating Scales; Dose-Response Relationship, Drug; Quality of Life; Adult; Female; Male
RMID: 0030005896
DOI: 10.1176/ps.50.1.101
Appears in Collections:Psychiatry publications

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