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|Title:||Clinical chemistry values and tissue enzyme activities in western barred bandicoots (Perameles bougainville)|
|Citation:||Veterinary Clinical Pathology, 2008; 37(2):221-224|
|Publisher:||Amer Soc Veterinary Clinical Pathology|
|Mark D. Bennett, Lucy Woolford, Amanda J. O’Hara, Philip K. Nicholls, Kristin S. Warren|
|Abstract:||<h4>Background</h4>The western barred bandicoot, Perameles bougainville, is an endangered Australian marsupial species whose survival is threatened by a papillomatosis and carcinomatosis syndrome. Investigations to characterize this syndrome would benefit from species-specific clinical chemistry data.<h4>Objectives</h4>The purpose of this study was to determine plasma biochemical reference values and to determine enzyme activities in various tissues of P. bougainville.<h4>Methods</h4>Heparinized blood samples were collected by jugular venipuncture from 53 clinically healthy bandicoots of both sexes and at 3 geographic locations. Plasma was analyzed for routine clinical chemistry variables using an automated biochemistry analyzer. Tissues obtained following humane euthanasia of 3 bandicoots were analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatine kinase (CK), alpha-amylase (AML), and gamma-glutamyltransferase (GGT) activities.<h4>Results</h4>Significant differences in the results were found for animals based on geographic location and sex; hence, results were expressed as minimum and maximum values. A population reference interval was calculated for AST activity (20-283 U/L). ALT was found mainly in the liver, with lower levels in cardiac and skeletal muscle and kidneys. AST was detectable in many tissues, including the heart, liver, kidneys, and central nervous system; CK was found in skeletal and cardiac muscle and central nervous system; AML was found in the pancreas; and GGT was found mainly in kidneys with lower levels in the intestines and pancreas.<h4>Conclusions</h4>These findings will facilitate the interpretation of clinical chemistry results from P. bougainville and thereby inform population management and clinical decision-making.|
|Keywords:||Clinical chemistry; enzymology; marsupial; Perameles bougainville; Peramelidae; reference interval|
|Rights:||©2008 American Society for Veterinary Clinical Pathology|
|Appears in Collections:||Animal and Veterinary Sciences publications|
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