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Type: Journal article
Title: Mesenchymal stem cell-organized bone marrow elements: an alternative hematopoietic progenitor resource
Author: Miura, Y.
Gao, Z.
Miura, M.
Seo, B.
Sonoyama, W.
Chen, W.
Gronthos, S.
Zhang, L.
Shi, S.
Citation: Stem Cells, 2006; 24(11):2428-2436
Publisher: Alphamed Press
Issue Date: 2006
ISSN: 1066-5099
Statement of
Yasuo Miura, Zhigang Gao, Masako Miura, Byoung-Moo Seo, Wataru Sonoyama, Wanjun Chen, Stan Gronthos, Li Zhang, Songtao Shi
Abstract: Bone marrow-derived mesenchymal stem cells (BMMSCs) are multipotent postnatal stem cells that have been used for the treatment of bone defects and graft-versus-host diseases in clinics. In this study, we found that subcutaneously transplanted human BMMSCs are capable of organizing hematopoietic progenitors of recipient origin. These hematopoietic cells expressed multiple lineages of hematopoietic cell associated markers and were able to rescue lethally irradiated mice, with successful engraftment in the recipient, suggesting a potential bone marrow (BM) resource for stem cell therapies. Furthermore, we found that platelet-derived growth factor (PDGF) promotes the formation of BMMSC-generated BM niches through upregulation of β-catenin, implying that the PDGF pathway contributes to the formation of ectopic BM. These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value.
Keywords: Mesenchymal stem cell
Hematopoietic stem cell
Platelet-derived growth factor
Bone marrow organ system
Rights: Copyright © 2006 AlphaMed Press
DOI: 10.1634/stemcells.2006-0089
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