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Type: Journal article
Title: Maternal nutrition and the programming of obesity: the brain
Author: Muhlhausler, B.
Adam, C.
McMillen, I.
Citation: Organogenesis, 2008; 4(3):144-152
Publisher: Landes Bioscience
Issue Date: 2008
ISSN: 1547-6278
Statement of
Beverly Sara Mühlhäusler, Clare L. Adam and I. Caroline McMillen
Abstract: The increasing incidence of obesity in the developed and developing world in the last decade has led to a need to define our understanding of the physiological mechanisms which can predispose individuals to weight gain in infancy, childhood and adulthood. There is now a considerable body of evidence which has shown that the pathway to obesity may begin very early in life, and that exposure to an inappropriate level of nutrition during prenatal and/or early postnatal development can predispose individuals to obesity in later life The brain is at the heart of the regulation of appetite and food preferences, and it is increasingly being recognised that the development of central appetitive structures is acutely sensitive to the nutritional environment both before and immediately after birth. This review will summarise the body of work which has highlighted the critical role of the brain in the early origins of obesity and presents some perspectives as to the potential application of these research findings in the clinical setting.
Keywords: fetal programming; appetite; obesity; leptin; neuropeptides
Rights: ©2008 Landes Bioscience
RMID: 0020108827
DOI: 10.4161/org.4.3.6503
Appears in Collections:Agriculture, Food and Wine publications

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