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https://hdl.handle.net/2440/66125
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Type: | Journal article |
Title: | Mesenchymal lineage precursor cells induce vascular network formation in ischemic myocardium |
Author: | Martens, T. See, F. Shuster, M. Sondermeijer, H. Hefti, M. Zannettino, A. Gronthos, S. Seki, T. Itescu, S. |
Citation: | Nature Reviews Cardiology, 2006; 3(Suppl 1):18-22 |
Publisher: | Nature Publishing Group |
Issue Date: | 2006 |
ISSN: | 1743-4297 1743-4300 |
Statement of Responsibility: | Timothy P Martens, Fiona See, Michael D Schuster, Hugo P Sondermeijer, Marco M Hefti, Andrew Zannettino, Stan Gronthos, Tetsunori Seki and Silviu Itescu |
Abstract: | Mesenchymal lineage precursors can be reproducibly isolated from adult mammalian bone marrow and grown in culture. Immunoselection with monoclonal antibodies against STRO-1 and vascular-cell-adhesion molecule 1 (VCAM1/CD106) prior to expansion results in a 1,000-fold enrichment of mesenchymal precursors compared to standard isolation techniques. Intramyocardial injection of human STRO-1-selected precursors in an athymic rat model of acute myocardial infarction results in induction of vascular network formation and arteriogenesis coupled with global functional cardiac recovery. |
Keywords: | cardiac myogenesis cardiac neovascularization mesenchymal precursor cells STRO-1 VCAM1 |
Rights: | © 2006 Nature Publishing Group |
DOI: | 10.1038/ncpcardio0404 |
Published version: | http://dx.doi.org/10.1038/ncpcardio0404 |
Appears in Collections: | Aurora harvest Medicine publications |
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