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Type: Journal article
Title: The role of the chemokine CXCL12 in osteoclastogenesis
Author: Gronthos, S.
Zannettino, A.
Citation: Trends in Endocrinology and Metabolism, 2007; 18(3):108-113
Publisher: Elsevier Science London
Issue Date: 2007
ISSN: 1043-2760
Statement of
Stan Gronthos and Andrew C.W. Zannettino
Abstract: The chemokine CXCL12 (variously termed stromal-derived factor 1 or B cell-stimulating factor) is a highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the postnatal organism. Although considered an important factor in normal bone metabolism, recent studies implicate CXCL12 in the pathogenesis of several diseases involving the skeleton, including rheumatoid arthritis and cancers that metastasize to bone. Recent studies have highlighted an emerging role for CXCL12 in the processes of physiological and pathological bone remodelling.
Keywords: Osteoclasts; Animals; Humans; Bone Resorption; Chemokines, CXC; Bone Remodeling; Cell Differentiation; Models, Biological; Chemokine CXCL12
Rights: © 2007 Elsevier Ltd. All rights reserved.
RMID: 0020102215
DOI: 10.1016/j.tem.2007.02.002
Appears in Collections:Medicine publications

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