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Type: Journal article
Title: INSL3 in the ruminant: A powerful indicator of gender- and genetic-specific feto-maternal dialogue
Author: Anand Ivell, R.
Hiendleder, S.
Vinoles, C.
Martin, G.
Fitzsimmons, C.
Eurich, A.
Hafen, B.
Ivell, R.
Citation: PLoS One, 2011; 6(5):1-7
Publisher: Public Library of Science
Issue Date: 2011
ISSN: 1932-6203
Statement of
Ravinder Anand-Ivell, Stefan Hiendleder, Carolina Vinõles, Graeme B. Martin, Carolyn Fitzsimmons, Andrea Eurich, Bettina Hafen and Richard Ivell
Abstract: The hormone Insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells from both fetal and adult testes. Consequently, it is a major gender-specific circulating hormone in the male fetus, where it is responsible for the first phase of testicular descent, and in the adult male. In most female mammals, circulating levels are very low, corresponding to only a small production of INSL3 by the mature ovaries. Female ruminants are exceptional in exhibiting high INSL3 gene expression by the thecal cells of antral follicles and by the corpora lutea. We have developed a specific and sensitive immunoassay to measure ruminant INSL3 and show that, corresponding to the high ovarian gene expression, non-pregnant adult female sheep and cows have up to four times the levels observed in other female mammals. Significantly, this level declines during mid-pregnancy in cows carrying a female fetus, in which INSL3 is undetectable. However, in cows carrying a male fetus, circulating maternal INSL3 becomes elevated further, presumably due to the transplacental transfer of fetal INSL3 into the maternal circulation. Within male fetal blood, INSL3 is high in mid-pregnancy (day 153) corresponding to the first transabdominal phase of testicular descent, and shows a marked dependence on paternal genetics, with pure bred or hybrid male fetuses of Bos taurus (Angus) paternal genome having 30% higher INSL3 levels than those of Bos indicus (Brahman) paternity. Thus INSL3 provides the first example of a gender-specific fetal hormone with the potential to influence both placental and maternal physiology.
Keywords: Ovary; Leydig Cells; Fetus; Placenta; Animals; Ruminants; Cattle; Sheep; Insulin; Proteins; Mothers; Sex Factors; Gene Expression; Pregnancy; Maternal-Fetal Exchange; Female; Male
Rights: © 2011 Anand-Ivell et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0020110879
DOI: 10.1371/journal.pone.0019821
Appears in Collections:Obstetrics and Gynaecology publications

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