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|Title:||Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain|
|Citation:||Brain Behavior and Immunity, 2011; 25(7):1322-1332|
|Publisher:||Academic Press Inc|
|Peter M. Grace, Paul E. Rolan and Mark R. Hutchinson|
|Abstract:||Recent evidence implicates an adaptive immune response in the central nervous system (CNS) mechanisms of neuropathic pain. This review identifies how neuropathic pain alters CNS immune privilege to facilitate T cell infiltration. Once in the CNS, T cells may interact with the local antigen presenting cells, microglia, via the major histocompatibility complex and the costimulatory molecules CD40 and B7. In this way, T cells may contribute to the maintenance of neuropathic pain through pro-inflammatory interactions with microglia and by facilitating the activation of astrocytes in the spinal dorsal horn. Based on the evidence presented in this review, we suggest that this bidirectional, pro-inflammatory system of neurons, glia and T cells in neuropathic pain should be renamed the pentapartite synapse, and identifies the latest member as a potential disease-modifying therapeutic target.|
|Keywords:||Allodynia; Central nervous system; Glia; Neuropathic pain; T cell; Immunological synapse|
|Rights:||Copyright © 2011 Elsevier Inc. All rights reserved.|
|Appears in Collections:||Pharmacology publications|
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