Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/66445
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sidjabat, H. | - |
dc.contributor.author | Chin, J. | - |
dc.contributor.author | Chapman, T. | - |
dc.contributor.author | Wu, K. | - |
dc.contributor.author | Ulett, G. | - |
dc.contributor.author | Ong, C. | - |
dc.contributor.author | Schembri, M. | - |
dc.contributor.author | Johnson, J. | - |
dc.contributor.author | Trott, D. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Microbes and Infection: a journal on infectious agents and host defenses, 2009; 11(1):100-107 | - |
dc.identifier.issn | 1286-4579 | - |
dc.identifier.issn | 1769-714X | - |
dc.identifier.uri | http://hdl.handle.net/2440/66445 | - |
dc.description.abstract | The study established the virulence potential of multidrug-resistant Escherichia coli (MDREC) isolates from nosocomial infections in hospitalised dogs. The isolates were resistant to fluoroquinolones, belonged to two distinct clonal groups (CG1 and CG2) and contained a plasmid-mediated AmpC (CMY-7) beta-lactamase. CG1 isolates (n=14) possessed two of 36 assayed extraintestinal virulence genes (iutA and traT) and belonged to phylogenetic group A, whereas CG2 isolates (n=19) contained four such genes (iutA, ibeA, fimH and kpsMT K5) and belonged to group D. In a mouse gastrointestinal tract colonisation model, colonisation by index CG1 strain C1 was transient, in contrast to the index CG2 strain C2b, which persisted up to 40days post-inoculation. In a mouse subcutaneous challenge model, both strains were less virulent than archetypal group B2 extraintestinal pathogenic E. coli (ExPEC) strain CFT073; strain C1 caused no systemic signs and strain C2b was lethal to only one of six mice. In a mouse urinary tract infection model, strain C2b colonised the mouse bladder over 2 logs higher compared to strain C1. Whilst both groups of canine MDREC appear less virulent than a reference human ExPEC strain, CG2 strains have greater capacity for colonisation and virulence. | - |
dc.description.statementofresponsibility | Hanna E. Sidjabat, James J.-C. Chin, Toni Chapman, Kent Wu, Glen C. Ulett, Cheryl Y. Ong, Mark A. Schembri, James R. Johnson, Darren J. Trott | - |
dc.language.iso | en | - |
dc.publisher | Editions Scientifiques Medicales Elsevier | - |
dc.rights | Copyright © 2008 Published by Elsevier Masson SAS | - |
dc.source.uri | http://dx.doi.org/10.1016/j.micinf.2008.10.014 | - |
dc.subject | Virulence | - |
dc.subject | Phylogeny | - |
dc.subject | Multidrug-resistant E. coli | - |
dc.title | Colonisation dynamics and virulence of two clonal groups of multidrug-resistant Escherichia coli isolated from dogs | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.micinf.2008.10.014 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Trott, D. [0000-0002-8297-5770] | - |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 5 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.