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Type: Journal article
Title: Linkage of regulators of TGF-β activity in the fetal ovary to polycystic ovary syndrome
Other Titles: Linkage of regulators of TGF-beta activity in the fetal ovary to polycystic ovary syndrome
Author: Hatzirodos, N.
Bayne, R.
Irving-Rodgers, H.
Hummitzsch, K.
Sabatier, L.
Lee, S.
Bonner, W.
Gibson, M.
Rainey, W.
Carr, B.
Mason, H.
Reinhardt, D.
Anderson, R.
Rodgers, R.
Citation: The FASEB Journal, 2011; 25(7):2256-2265
Publisher: Federation Amer Soc Exp Biol
Issue Date: 2011
ISSN: 0892-6638
Abstract: Although not often discussed, the ovaries of women with polycystic ovary syndrome (PCOS) show all the hallmarks of increased TGF-β activity, with increased amounts of fibrous tissue and collagen in the ovarian capsule or tunica albuginea and ovarian stroma. Recent studies suggest that PCOS could have fetal origins. Genetic studies of PCOS have also found linkage with a microsatellite located in intron 55 of the extracellular matrix protein fibrillin 3. Fibrillins regulate TGF-β bioactivity in tissues by binding latent TGF-β binding proteins. We therefore examined expression of fibrillins 1-3, latent TGF-β binding proteins 1-4, and TGF-β 1-3 in bovine and human fetal ovaries at different stages of gestation and in adult ovaries. We also immunolocalized fibrillins 1 and 3. The results indicate that TGF-β pathways operate during ovarian fetal development, but most important, we show fibrillin 3 is present in the stromal compartments of fetal ovaries and is highly expressed at a critical stage early in developing human and bovine fetal ovaries when stroma is expanding and follicles are forming. These changes in expression of fibrillin 3 in the fetal ovary could lead to a predisposition to develop PCOS in later life.
Keywords: Ovary
Ovarian Follicle
Polycystic Ovary Syndrome
Microfilament Proteins
Transforming Growth Factor beta
Reverse Transcriptase Polymerase Chain Reaction
Gene Expression Regulation, Developmental
Transforming Growth Factor beta1
Transforming Growth Factor beta2
Latent TGF-beta Binding Proteins
Transforming Growth Factor beta3
Rights: Copyright © 2011 by the Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.11-181099
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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