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Type: Journal article
Title: Identification of Streptococcus pneumoniae Cps2C residues that affect capsular polysaccharide polymerization, cell wall ligation, and Cps2D phosphorylation
Author: Byrne, J.
Morona, J.
Paton, J.
Morona, R.
Citation: Journal of Bacteriology, 2011; 193(9):2341-2346
Publisher: Amer Soc Microbiology
Issue Date: 2011
ISSN: 0021-9193
Statement of
James P. Byrne, Judy K. Morona, James C. Paton, and Renato Morona
Abstract: A number of single amino acid substitutions throughout Streptococcus pneumoniae Cps2C were found to affect its function and confer either a mucoid or a small colony phenotype. These mutants exhibit significant changes in capsular polysaccharide (CPS) profile relative to that of wild-type pneumococci. The introduced mutations affect either polymerization or ligation of CPS to the cell wall and/or Cps2D phosphorylation.
Keywords: Cell Wall; Streptococcus pneumoniae; Polysaccharides, Bacterial; Bacterial Capsules; Bacterial Proteins; Amino Acid Substitution; Gene Expression Regulation, Bacterial; Amino Acid Sequence; Mutation
Rights: Copyright © 2011, American Society for Microbiology. All Rights Reserved.
RMID: 0020105691
DOI: 10.1128/JB.00074-11
Appears in Collections:Microbiology and Immunology publications

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