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|Title:||Identification of Streptococcus pneumoniae Cps2C residues that affect capsular polysaccharide polymerization, cell wall ligation, and Cps2D phosphorylation|
|Citation:||Journal of Bacteriology, 2011; 193(9):2341-2346|
|Publisher:||Amer Soc Microbiology|
|James P. Byrne, Judy K. Morona, James C. Paton, and Renato Morona|
|Abstract:||A number of single amino acid substitutions throughout Streptococcus pneumoniae Cps2C were found to affect its function and confer either a mucoid or a small colony phenotype. These mutants exhibit significant changes in capsular polysaccharide (CPS) profile relative to that of wild-type pneumococci. The introduced mutations affect either polymerization or ligation of CPS to the cell wall and/or Cps2D phosphorylation.|
|Keywords:||Cell Wall; Streptococcus pneumoniae; Polysaccharides, Bacterial; Bacterial Capsules; Bacterial Proteins; Amino Acid Substitution; Gene Expression Regulation, Bacterial; Amino Acid Sequence; Mutation|
|Rights:||Copyright © 2011, American Society for Microbiology. All Rights Reserved.|
|Appears in Collections:||Microbiology and Immunology publications|
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