Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/66685
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dc.contributor.author | van Eyk, C. | - |
dc.contributor.author | O'Keefe, L. | - |
dc.contributor.author | Lawlor, K. | - |
dc.contributor.author | Samaraweera, S. | - |
dc.contributor.author | McLeod, C. | - |
dc.contributor.author | Price, G. | - |
dc.contributor.author | Venter, D. | - |
dc.contributor.author | Richards, R. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Human Molecular Genetics, 2011; 20(14):2783-2794 | - |
dc.identifier.issn | 0964-6906 | - |
dc.identifier.issn | 1460-2083 | - |
dc.identifier.uri | http://hdl.handle.net/2440/66685 | - |
dc.description.abstract | Recent evidence supports a role for RNA as a common pathogenic agent in both the ‘polyglutamine’ and ‘untranslated’ dominant expanded repeat disorders. One feature of all repeat sequences currently associated with disease is their predicted ability to form a hairpin secondary structure at the RNA level. In order to investigate mechanisms by which hairpin-forming repeat RNAs could induce neurodegeneration, we have looked for alterations in gene transcript levels as hallmarks of the cellular response to toxic hairpin repeat RNAs. Three disease-associated repeat sequences—CAG, CUG and AUUCU—were specifically expressed in the neurons of Drosophila and resultant common transcriptional changes assessed by microarray analyses. Transcripts that encode several components of the Akt/Gsk3-β signalling pathway were altered as a consequence of expression of these repeat RNAs, indicating that this pathway is a component of the neuronal response to these pathogenic RNAs and may represent an important common therapeutic target in this class of diseases. | - |
dc.description.statementofresponsibility | Clare L. van Eyk, Louise V. O'Keefe, Kynan T. Lawlor, Saumya E. Samaraweera, Catherine J. McLeod, Gareth R. Price, Deon J. Venter and Robert I. Richards | - |
dc.language.iso | en | - |
dc.publisher | Oxford Univ Press | - |
dc.rights | © The Author 2011. Copyright © 2011 Oxford University Press This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.source.uri | http://dx.doi.org/10.1093/hmg/ddr177 | - |
dc.subject | Animals | - |
dc.subject | Drosophila melanogaster | - |
dc.subject | Neurodegenerative Diseases | - |
dc.subject | Glycogen Synthase Kinase 3 | - |
dc.subject | Drosophila Proteins | - |
dc.subject | RNA | - |
dc.subject | Signal Transduction | - |
dc.subject | Gene Expression | - |
dc.subject | Repetitive Sequences, Nucleic Acid | - |
dc.subject | Proto-Oncogene Proteins c-akt | - |
dc.subject | Glycogen Synthase Kinase 3 beta | - |
dc.title | Perturbation of the Akt/Gsk3-beta signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/hmg/ddr177 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/207830 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/453674 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/627183 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | van Eyk, C. [0000-0003-0345-9944] | - |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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hdl_66685.pdf | Published version | 515.6 kB | Adobe PDF | View/Open |
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