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https://hdl.handle.net/2440/66793
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Type: | Journal article |
Title: | Armanni-Ebstein phenomenon and hypothermia |
Author: | Zhou, C. Byard, R. |
Citation: | Forensic Science International, 2011; 206(1-3):e82-e84 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2011 |
ISSN: | 0379-0738 1872-6283 |
Statement of Responsibility: | Chong Zhou, Roger W. Byard |
Abstract: | Retrospective review was undertaken of 46 cases of lethal hypothermia for the presence of subnuclear vacuolization of renal tubular epithelial cells. Fifteen of the 46 cases (33%) had renal tubular vacuolization typical of the Armanni-Ebstein phenomenon. The age range was 30-87 years (average 59 years) with a male to female ratio of 6:9. Nine of the 15 cases with Armanni-Ebstein changes (60%) had a history of diabetes mellitus, and in seven of these vitreous humour biochemical analyses were performed, all of which revealed diabetic ketoacidosis (vitreous glucose levels = 32.9-85.3 mmol/L; β-hydroxybutyrate = 7.4-20 mmol/L). This study has confirmed the association between hypothermia and renal tubular epithelial vacuolization, but in addition raises the prospect that this may be contributed to in some cases by underlying diabetic ketoacidosis. Hypothermic deaths should, therefore, raise the possibility of diabetes mellitus and initiate postmortem biochemical measurement of vitreous humor glucose and β-hydroxybutyrate levels. |
Keywords: | Armanni-Ebstein phenomenon Renal tubular vacuolization Hypothermia Diabetes mellitus Ketoacidosis |
Rights: | Copyright © 2010 Elsevier Ireland Ltd. Published by Elsevier Ireland Ltd. All rights reserved. |
DOI: | 10.1016/j.forsciint.2010.08.018 |
Published version: | http://dx.doi.org/10.1016/j.forsciint.2010.08.018 |
Appears in Collections: | Aurora harvest Pathology publications |
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