Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/66882
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dc.contributor.authorKemoun, P.en
dc.contributor.authorGronthos, S.en
dc.contributor.authorSnead, M.en
dc.contributor.authorRue, J.en
dc.contributor.authorCourtois, B.en
dc.contributor.authorVaysse, F.en
dc.contributor.authorSalles, J.en
dc.contributor.authorBrunel, G.en
dc.date.issued2011en
dc.identifier.citationBiomaterials, 2011; 32(30):7375-7388en
dc.identifier.issn0142-9612en
dc.identifier.issn1878-5905en
dc.identifier.urihttp://hdl.handle.net/2440/66882-
dc.description.abstractPeriodontitis is a chronic-, infectious-disease of the human periodontium that is characterized by the loss of supporting tissues surrounding the tooth such as the periodontal ligament (PDL), cementum and alveolar bone. Regeneration of the periodontium is dependent on the participation of mesenchymal stem/stromal cells (MSC) resident in the PDL. Enamel matrix derivative (EMD), an extract from immature porcine enamel rich in amelogenin protein but that also contain bone morphogenetic protein (BMP), is used to treat periodontal defects. The effects of EMD on MSC cells of the PDL are not well characterized. In this in vitro study, we identify PDL progenitor cells from multiple individuals and demonstrate that EMD stimulates them. We show that the effect of EMD on cell proliferation and migration is mediated through the amelogenin it contains, while the differentiation of these progenitor cells to cell types of mineralized tissue is mainly due to BMP signaling.en
dc.description.statementofresponsibilityPhilippe Kémoun, Stan Gronthos, Malcolm L. Snead, Jacqueline Rue, Bruno Courtois, Frédéric Vaysse, Jean-Pierre Salles, Gérard Brunelen
dc.language.isoenen
dc.publisherElsevier Sci Ltden
dc.rightsCopyright © 2011 Elsevier Ltd. All rights reserved.en
dc.subjectPeriodontium; Mesenchymal stem cell; Bone morphogenetic protein; Amelogenin; Enamel matrix derivative (EMD)en
dc.titleThe role of cell surface markers and enamel matrix derivatives on human periodontal ligament mesenchymal progenitor responses in vitroen
dc.typeJournal articleen
dc.identifier.rmid0020112622en
dc.identifier.doi10.1016/j.biomaterials.2011.06.043en
dc.identifier.pubid27793-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidGronthos, S. [0000-0002-6225-3084]en
Appears in Collections:Medicine publications

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