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dc.contributor.authorKemoun, P.en
dc.contributor.authorGronthos, S.en
dc.contributor.authorSnead, M.en
dc.contributor.authorRue, J.en
dc.contributor.authorCourtois, B.en
dc.contributor.authorVaysse, F.en
dc.contributor.authorSalles, J.en
dc.contributor.authorBrunel, G.en
dc.identifier.citationBiomaterials, 2011; 32(30):7375-7388en
dc.description.abstractPeriodontitis is a chronic-, infectious-disease of the human periodontium that is characterized by the loss of supporting tissues surrounding the tooth such as the periodontal ligament (PDL), cementum and alveolar bone. Regeneration of the periodontium is dependent on the participation of mesenchymal stem/stromal cells (MSC) resident in the PDL. Enamel matrix derivative (EMD), an extract from immature porcine enamel rich in amelogenin protein but that also contain bone morphogenetic protein (BMP), is used to treat periodontal defects. The effects of EMD on MSC cells of the PDL are not well characterized. In this in vitro study, we identify PDL progenitor cells from multiple individuals and demonstrate that EMD stimulates them. We show that the effect of EMD on cell proliferation and migration is mediated through the amelogenin it contains, while the differentiation of these progenitor cells to cell types of mineralized tissue is mainly due to BMP signaling.en
dc.description.statementofresponsibilityPhilippe Kémoun, Stan Gronthos, Malcolm L. Snead, Jacqueline Rue, Bruno Courtois, Frédéric Vaysse, Jean-Pierre Salles, Gérard Brunelen
dc.publisherElsevier Sci Ltden
dc.rightsCopyright © 2011 Elsevier Ltd. All rights reserved.en
dc.subjectPeriodontium; Mesenchymal stem cell; Bone morphogenetic protein; Amelogenin; Enamel matrix derivative (EMD)en
dc.titleThe role of cell surface markers and enamel matrix derivatives on human periodontal ligament mesenchymal progenitor responses in vitroen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidGronthos, S. [0000-0002-6225-3084]en
Appears in Collections:Medicine publications

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