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Type: Journal article
Title: The role of cell surface markers and enamel matrix derivatives on human periodontal ligament mesenchymal progenitor responses in vitro
Author: Kemoun, P.
Gronthos, S.
Snead, M.
Rue, J.
Courtois, B.
Vaysse, F.
Salles, J.
Brunel, G.
Citation: Biomaterials, 2011; 32(30):7375-7388
Publisher: Elsevier Sci Ltd
Issue Date: 2011
ISSN: 0142-9612
Statement of
Philippe Kémoun, Stan Gronthos, Malcolm L. Snead, Jacqueline Rue, Bruno Courtois, Frédéric Vaysse, Jean-Pierre Salles, Gérard Brunel
Abstract: Periodontitis is a chronic-, infectious-disease of the human periodontium that is characterized by the loss of supporting tissues surrounding the tooth such as the periodontal ligament (PDL), cementum and alveolar bone. Regeneration of the periodontium is dependent on the participation of mesenchymal stem/stromal cells (MSC) resident in the PDL. Enamel matrix derivative (EMD), an extract from immature porcine enamel rich in amelogenin protein but that also contain bone morphogenetic protein (BMP), is used to treat periodontal defects. The effects of EMD on MSC cells of the PDL are not well characterized. In this in vitro study, we identify PDL progenitor cells from multiple individuals and demonstrate that EMD stimulates them. We show that the effect of EMD on cell proliferation and migration is mediated through the amelogenin it contains, while the differentiation of these progenitor cells to cell types of mineralized tissue is mainly due to BMP signaling.
Keywords: Periodontium; Mesenchymal stem cell; Bone morphogenetic protein; Amelogenin; Enamel matrix derivative (EMD)
Rights: Copyright © 2011 Elsevier Ltd. All rights reserved.
RMID: 0020112622
DOI: 10.1016/j.biomaterials.2011.06.043
Appears in Collections:Medicine publications

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