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https://hdl.handle.net/2440/66884
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dc.contributor.author | Gentilcore, D. | - |
dc.contributor.author | Vanis, L. | - |
dc.contributor.author | Teng, J. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Buckley, J. | - |
dc.contributor.author | Rayner, C. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Jones, K. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | The British Journal of Nutrition: an international journal of nutritional science, 2011; 106(4):583-587 | - |
dc.identifier.issn | 0007-1145 | - |
dc.identifier.issn | 1475-2662 | - |
dc.identifier.uri | http://hdl.handle.net/2440/66884 | - |
dc.description.abstract | In healthy older subjects, the glycaemic response to carbohydrate-containing meals is dependent on gastric emptying and intestinal absorption; when the latter is slowed, the magnitude of the rise in glucose is attenuated. The oligosaccharide α-cyclodextrin has been reported to diminish the glycaemic response to starch in young adults; this effect has been attributed to the inhibition of pancreatic amylase. We examined the effects of α-cyclodextrin on gastric emptying of, and the glycaemic and insulinaemic responses to, oral sucrose in healthy older subjects; as sucrose is hydrolysed by intestinal disaccharides, any effect(s) of α-cyclodextrin would not be attributable to amylase inhibition. A total of ten subjects (seven males and three females, age 68–76 years) were studied on 2 d. Gastric emptying, blood glucose and serum insulin were measured after ingestion of a 300 ml drink containing 100 g sucrose, labelled with 99mTc-sulphur colloid, with or without 10 g α-cyclodextrin. Gastric emptying was slowed slightly by α-cyclodextrin; this effect was evident between 135 and 195 min and was associated with a slight increase (P < 0·05) in distal stomach retention. After α-cyclodextrin, blood glucose was slightly less (P < 0·05) at 60 min, and serum insulin was less (P < 0·0005) at 90 and 120 min. There was no difference in the incremental areas under the curve (iAUC) for blood glucose, but there was a trend for the iAUC for serum insulin to be lower (P = 0·09) after α-cyclodextrin. We conclude that in a dose of 10 g, α-cyclodextrin has modest effects to slow gastric emptying of, and modify the glycaemic and insulinaemic responses to, oral sucrose, probably due to delayed intestinal carbohydrate absorption. | - |
dc.description.statementofresponsibility | Diana Gentilcore, Lora Vanis, Jasmine C. Teng, Judith M. Wishart, Jonathan D. Buckley, Christopher K. Rayner, Michael Horowitz and Karen L. Jones | - |
dc.language.iso | en | - |
dc.publisher | C A B I Publishing | - |
dc.rights | Copyright © The Authors 2011 | - |
dc.source.uri | http://dx.doi.org/10.1017/s0007114511000444 | - |
dc.subject | Gastric emptying: Glycaemia: Cyclodextrin: Elderly | - |
dc.title | The oligosaccharide α-cyclodextrin has modest effects to slow gastric emptying and modify the glycaemic response to sucrose in healthy older adults | - |
dc.title.alternative | The oligosaccharide alpha-cyclodextrin has modest effects to slow gastric emptying and modify the glycaemic response to sucrose in healthy older adults | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1017/S0007114511000444 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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